Graft-versus-Host Disease and Severe Combined Immunodeficiency

Thomas A. Seemayer, Robert P. Bolande, Wayne S. Lapp, Marilyn S. Pollack, Neal Flomenberg, Dahlia V. Kirkpatrick, Neena Kapoor, bo Dupont, Richard J. O'reilly

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: In the September 9 issue Pollack and her colleagues reported that they had found maternal E-rosette-positive, DR-positive T lymphocytes in the peripheral blood of 4 of 16 infants (5 to 12 months of age) with severe combined immunodeficiency. The features of classic graft-versus-host disease were present in only one of the infants, although the authors queried whether certain features of the autosomal recessive form of immunodeficiency might represent the consequence of an intrauterine graft-versus-host reaction induced by the maternal T lymphocytes. Under appropriate experimental conditions in mice, graft-versus-host reactions induce a state of permanent immunodeficiency2,3 characterized by.

Original languageEnglish (US)
Pages (from-to)160-161
Number of pages2
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jan 20 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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