Gonadotropin releasing hormone does not affect steroidogenesis in JEG-3 cells

Andrew J. Bauer; Alan Daniel; Lili Khozeimeh; Gary L. Francis

Gonadotropin releasing hormone does not affect steroidogenesis in JEG-3 cells

Andrew J. Bauer, Alan Daniel, Lili Khozeimeh, Gary L. Francis

Research output: Contribution to journal › Article › peer-review

Abstract

Gonadotropin releasing hormone (GnRH) affects ovarian and testicular steroidogenesis, is produced by the placenta, and increases chorionic gonadotropin (hCG) production in preterm placenta. It was hypothesized that GnRH might also regulate placental synthesis of progesterone (P) and estradiol (E₂) and the effects were studied of GnRH and the [D-Trp⁶]-LH-RH analog on the production of P, E₂, and hCG by JEG-3 choriocarcinoma cells. Neither GnRH nor [D-Trp⁶]-LH-RH had any effect on the production of P, E₂ or hCG. Our findings are similar to a previous observation which showed GnRH did not increase hCG in term placenta, but differed from preterm placenta in which GnRH increased hCG. This suggests there could be maturational changes in the placental response to GnRH and that JEG-3 cells more closely resemble term placenta. It is our conclusion that although GnRH and the GnRH receptor are found in the placenta, GnRH might have no effect on steroid hormone synthesis near term.

Original language	English (US)
Pages (from-to)	57-64
Number of pages	8
Journal	Annals of Clinical and Laboratory Science
Volume	28
Issue number	1
State	Published - Mar 12 1998
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology and Allergy
Pathology and Forensic Medicine
Immunology
Molecular Biology
Hematology
Clinical Biochemistry
Medical Laboratory Technology

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title = "Gonadotropin releasing hormone does not affect steroidogenesis in JEG-3 cells",

abstract = "Gonadotropin releasing hormone (GnRH) affects ovarian and testicular steroidogenesis, is produced by the placenta, and increases chorionic gonadotropin (hCG) production in preterm placenta. It was hypothesized that GnRH might also regulate placental synthesis of progesterone (P) and estradiol (E2) and the effects were studied of GnRH and the [D-Trp6]-LH-RH analog on the production of P, E2, and hCG by JEG-3 choriocarcinoma cells. Neither GnRH nor [D-Trp6]-LH-RH had any effect on the production of P, E2 or hCG. Our findings are similar to a previous observation which showed GnRH did not increase hCG in term placenta, but differed from preterm placenta in which GnRH increased hCG. This suggests there could be maturational changes in the placental response to GnRH and that JEG-3 cells more closely resemble term placenta. It is our conclusion that although GnRH and the GnRH receptor are found in the placenta, GnRH might have no effect on steroid hormone synthesis near term.",

author = "Bauer, {Andrew J.} and Alan Daniel and Lili Khozeimeh and Francis, {Gary L.}",

year = "1998",

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T1 - Gonadotropin releasing hormone does not affect steroidogenesis in JEG-3 cells

AU - Bauer, Andrew J.

AU - Daniel, Alan

AU - Khozeimeh, Lili

AU - Francis, Gary L.

PY - 1998/3/12

Y1 - 1998/3/12

N2 - Gonadotropin releasing hormone (GnRH) affects ovarian and testicular steroidogenesis, is produced by the placenta, and increases chorionic gonadotropin (hCG) production in preterm placenta. It was hypothesized that GnRH might also regulate placental synthesis of progesterone (P) and estradiol (E2) and the effects were studied of GnRH and the [D-Trp6]-LH-RH analog on the production of P, E2, and hCG by JEG-3 choriocarcinoma cells. Neither GnRH nor [D-Trp6]-LH-RH had any effect on the production of P, E2 or hCG. Our findings are similar to a previous observation which showed GnRH did not increase hCG in term placenta, but differed from preterm placenta in which GnRH increased hCG. This suggests there could be maturational changes in the placental response to GnRH and that JEG-3 cells more closely resemble term placenta. It is our conclusion that although GnRH and the GnRH receptor are found in the placenta, GnRH might have no effect on steroid hormone synthesis near term.

AB - Gonadotropin releasing hormone (GnRH) affects ovarian and testicular steroidogenesis, is produced by the placenta, and increases chorionic gonadotropin (hCG) production in preterm placenta. It was hypothesized that GnRH might also regulate placental synthesis of progesterone (P) and estradiol (E2) and the effects were studied of GnRH and the [D-Trp6]-LH-RH analog on the production of P, E2, and hCG by JEG-3 choriocarcinoma cells. Neither GnRH nor [D-Trp6]-LH-RH had any effect on the production of P, E2 or hCG. Our findings are similar to a previous observation which showed GnRH did not increase hCG in term placenta, but differed from preterm placenta in which GnRH increased hCG. This suggests there could be maturational changes in the placental response to GnRH and that JEG-3 cells more closely resemble term placenta. It is our conclusion that although GnRH and the GnRH receptor are found in the placenta, GnRH might have no effect on steroid hormone synthesis near term.

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