GnRH-LH secreting cells axis in the pituitary of the teleost Clarias batrachus responds to neuropeptide Y treatment: An immunocytochemical study

Archana Gaikwad, K. C. Biju, Nishikant Subhedar

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

An attempt has been made to immunocytochemically visualize the effect of neuropeptide Y (NPY) on the GnRH fibers and luteinizing hormone (LH) secreting cells in the pituitary of the catfish, Clarias batrachus. Two hours following the intracranial administration of NPY at the dose of 20ng/g body wt, a significant increase in the area occupied by the GnRH-like immunoreactive fibers, and population and size of the LH cells was observed. The treatment also resulted in considerable augmentation of immunoreactivity in the LH cells. Double immunolabeling revealed NPY fibers directly terminating on the LH cells. The results suggest that NPY may (a) stimulate some GnRH containing hypophysiotropic neuronal group in the brain, (b) promote anterograde transport of GnRH to the pituitary gland, and (c) up-regulate the LH cells.

Original languageEnglish (US)
Pages (from-to)126-133
Number of pages8
JournalGeneral and Comparative Endocrinology
Volume131
Issue number2
DOIs
StatePublished - Apr 2003
Externally publishedYes

Keywords

  • GnRH
  • Luteinizing hormone secreting cells
  • Neuropeptide Y
  • Pituitary
  • Reproduction
  • Teleost

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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