Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells

Robert A. Hromas, Paul A. Andrews, Michael P. Murphy, C. Patrick Burns

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210 PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to d,l-buthionine-S,R-sulfoximine reduced L1210 PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalCancer Letters
Volume34
Issue number1
DOIs
StatePublished - Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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