Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells

Robert A. Hromas; Paul A. Andrews; Michael P. Murphy; C. Patrick Burns

doi:10.1016/0304-3835(87)90067-X

Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells

Robert A. Hromas, Paul A. Andrews, Michael P. Murphy, C. Patrick Burns

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210 PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/^*. Exposure to d,l-buthionine-S,R-sulfoximine reduced L1210 PAM cells' glutathione content to nearly that of L1210/^* cells and abrogated the resistance to cisplatin.

Original language	English (US)
Pages (from-to)	9-13
Number of pages	5
Journal	Cancer Letters
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(87)90067-X
State	Published - Jan 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(87)90067-X

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title = "Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells",

abstract = "Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210 PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to d,l-buthionine-S,R-sulfoximine reduced L1210 PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin.",

author = "Hromas, {Robert A.} and Andrews, {Paul A.} and Murphy, {Michael P.} and Burns, {C. Patrick}",

note = "Funding Information: *Supported in part by PHS grants CA 31526, CA 2370, and CA 35309 from the National Cancer Institute, DHHS, and by the Clayton Foundation for Research, California Division. Address correspondence to: Robert A. Hromas, Department of Medicine, University Hospitals, Iowa City, IA 52242, U.S.A.)",

year = "1987",

month = jan,

doi = "10.1016/0304-3835(87)90067-X",

language = "English (US)",

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pages = "9--13",

journal = "Cancer Letters",

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T1 - Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells

AU - Hromas, Robert A.

AU - Andrews, Paul A.

AU - Murphy, Michael P.

AU - Burns, C. Patrick

N1 - Funding Information: *Supported in part by PHS grants CA 31526, CA 2370, and CA 35309 from the National Cancer Institute, DHHS, and by the Clayton Foundation for Research, California Division. Address correspondence to: Robert A. Hromas, Department of Medicine, University Hospitals, Iowa City, IA 52242, U.S.A.)

PY - 1987/1

Y1 - 1987/1

N2 - Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210 PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to d,l-buthionine-S,R-sulfoximine reduced L1210 PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin.

AB - Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210 PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to d,l-buthionine-S,R-sulfoximine reduced L1210 PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin.

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Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells

Abstract

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