Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210 PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to d,l-buthionine-S,R-sulfoximine reduced L1210 PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin.
ASJC Scopus subject areas
- Cancer Research