Glutaminolysis as a target for cancer therapy

L. Jin, G. N. Alesi, S. Kang

Research output: Contribution to journalReview articlepeer-review

304 Scopus citations

Abstract

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in these metabolic processes could provide novel approaches to improve cancer treatment. This review summarizes current findings on the role of glutaminolytic enzymes in human cancers and provides an update on the development of small molecule inhibitors to target glutaminolysis for cancer therapy.

Original languageEnglish (US)
Pages (from-to)3619-3625
Number of pages7
JournalOncogene
Volume35
Issue number28
DOIs
StatePublished - Jul 14 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'Glutaminolysis as a target for cancer therapy'. Together they form a unique fingerprint.

Cite this