Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats

Douglass L. Jackson, Christopher B. Graff, Jennelle Durnett Richardson, Kenneth M. Hargreaves

Research output: Contribution to journalArticlepeer-review

177 Scopus citations


While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar ( injection of l-glutamate (30 nmol) evokes a thermal hyperalgesic response in the paw withdrawal latencies of normal rats which is stereospecific. In addition, the injection of either the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 (10 nmol) acid (AMPA)/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (100 nmol) into hindpaws inflamed with carrageenan significantly reduced the thermal hyperalgesic response in rats. Collectively, these results suggest that excitatory amino acids activate a peripheral target which facilitates a hyperalgesic behavioral response to thermal stimulation via a receptor mediated process.

Original languageEnglish (US)
Pages (from-to)321-325
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - Sep 25 1995
Externally publishedYes


  • Analgesia
  • CNQX (6-cyano-7-nitroquinoxaline-2,3-dione)
  • Glutamate
  • Inflammation
  • MK-801
  • Pain

ASJC Scopus subject areas

  • Pharmacology


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