TY - JOUR
T1 - Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats
AU - Jackson, Douglass L.
AU - Graff, Christopher B.
AU - Richardson, Jennelle Durnett
AU - Hargreaves, Kenneth M.
PY - 1995/9/25
Y1 - 1995/9/25
N2 - While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar (i.pl.) injection of l-glutamate (30 nmol) evokes a thermal hyperalgesic response in the paw withdrawal latencies of normal rats which is stereospecific. In addition, the i.pl. injection of either the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 (10 nmol) acid (AMPA)/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (100 nmol) into hindpaws inflamed with carrageenan significantly reduced the thermal hyperalgesic response in rats. Collectively, these results suggest that excitatory amino acids activate a peripheral target which facilitates a hyperalgesic behavioral response to thermal stimulation via a receptor mediated process.
AB - While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar (i.pl.) injection of l-glutamate (30 nmol) evokes a thermal hyperalgesic response in the paw withdrawal latencies of normal rats which is stereospecific. In addition, the i.pl. injection of either the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 (10 nmol) acid (AMPA)/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (100 nmol) into hindpaws inflamed with carrageenan significantly reduced the thermal hyperalgesic response in rats. Collectively, these results suggest that excitatory amino acids activate a peripheral target which facilitates a hyperalgesic behavioral response to thermal stimulation via a receptor mediated process.
KW - Analgesia
KW - CNQX (6-cyano-7-nitroquinoxaline-2,3-dione)
KW - Glutamate
KW - Inflammation
KW - MK-801
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=0029126353&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029126353&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(95)00449-U
DO - 10.1016/0014-2999(95)00449-U
M3 - Article
C2 - 8666015
AN - SCOPUS:0029126353
SN - 0014-2999
VL - 284
SP - 321
EP - 325
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -