Glucose-Mediated Glucose Disposal at Baseline Insulin Is Impaired in IFG

Mariam Alatrach, Christina Agyin, Rucha Mehta, John Adams, Ralph A Defronzo, Muhammad A Abdul-ghani

Research output: Contribution to journalArticle

Abstract

Objective: To quantify glucose-mediated glucose disposal with and without basal insulin replacement and insulin-mediated glucose disposal in subjects with impaired fasting glucose (IFG). Research Design and Methods: We used the hyperglycemic/pancreatic clamp and stepped euglycemic clamp techniques to quantify glucose disposal and suppression of endogenous glucose production (EGP) in those with normal glucose tolerance (NGT; n = 14) and those with IFG (n = 14). Results: Total body glucose-mediated glucose uptake, measured with the hyperglycemic/pancreatic clamp, was not significantly affected by the basal plasma insulin levels in subjects with IFG and those with NGT. Compared with subjects with NGT, those with IFG had significantly lower glucose-mediated glucose uptake (by 15%) during the hyperglycemic clamp performed with and without basal insulin replacement. In contrast, insulin-mediated glucose disposal was comparable in both groups. The suppression of EGP by hyperglycemia was similar in both groups. However, the suppression of EGP by insulin was attenuated in those with IFG compared with those with NGT. Conclusions: The results of the present study have demonstrated that (i) glucose-mediated glucose disposal is impaired in those with IFG; (ii) insulin-mediated glucose uptake in IFG is normal; and (iii) insulin action to suppress EGP is impaired.

LanguageEnglish (US)
Pages163-171
Number of pages9
JournalThe Journal of clinical endocrinology and metabolism
Volume104
Issue number1
DOIs
StatePublished - Jan 1 2019

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Fasting
Insulin
Glucose
Clamping devices
Glucose Clamp Technique

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Glucose-Mediated Glucose Disposal at Baseline Insulin Is Impaired in IFG. / Alatrach, Mariam; Agyin, Christina; Mehta, Rucha; Adams, John; Defronzo, Ralph A; Abdul-ghani, Muhammad A.

In: The Journal of clinical endocrinology and metabolism, Vol. 104, No. 1, 01.01.2019, p. 163-171.

Research output: Contribution to journalArticle

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