Glucagon enhances growth of cultured human colorectal cancer cells in vitro

Mary Pat Moyer, J. Bradley Aust, Patricia S. Dixon, Barry A. Levine, Kenneth R Sirinek

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Early passage in vitro cultures of colorectal adenocarcinoma cells were used to determine if glucagon exerts a direct effect on growth of human colon cancer cells. Growth response assays indicated that glucagon generally stimulated growth between 2 and 10 μg/ml, with peak responses at 5 to 10 μg/ml. When glucagon-treated and control cultures were compared, 12 of the 14 cultures (86 percent) were stimulated by glucagon, with an increase in cells from 41 to 100 percent. The other two cultures did not respond to glucagon. These in vitro results suggest that glucagon may enhance growth of most colon cancer cells. Further studies on responsiveness to glucagon may help elucidate mechanisms of oncogenesis and suggest new therapeutic protocols for patients with colorectal cancer.

Original languageEnglish (US)
Pages (from-to)676-679
Number of pages4
JournalThe American Journal of Surgery
Volume150
Issue number6
DOIs
StatePublished - 1985
Externally publishedYes

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Glucagon
Colorectal Neoplasms
Growth
Colonic Neoplasms
In Vitro Techniques
Carcinogenesis
Adenocarcinoma

ASJC Scopus subject areas

  • Surgery

Cite this

Glucagon enhances growth of cultured human colorectal cancer cells in vitro. / Moyer, Mary Pat; Aust, J. Bradley; Dixon, Patricia S.; Levine, Barry A.; Sirinek, Kenneth R.

In: The American Journal of Surgery, Vol. 150, No. 6, 1985, p. 676-679.

Research output: Contribution to journalArticle

Moyer, Mary Pat ; Aust, J. Bradley ; Dixon, Patricia S. ; Levine, Barry A. ; Sirinek, Kenneth R. / Glucagon enhances growth of cultured human colorectal cancer cells in vitro. In: The American Journal of Surgery. 1985 ; Vol. 150, No. 6. pp. 676-679.
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