GLP-1 agonist-based therapies: An emerging new class of antidiabetic drug with potential cardioprotective effects

Melanie Sulistio, Curtis Carothers, Mandeep Mangat, Mike Lujan, Rene Oliveros, Robert Chilton

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Cardiovascular disease is a leading cause of death in the United States and across the world, and better therapies are constantly being sought to improve patient outcomes. Recent studies have brought our attention to the mechanisms of glucagon-like peptide 1 (GLP-1). Not only does it demonstrate beneficial effects in regard to cardiovascular risk factors (ie, diabetes, lipid management, and weight control), but it also has been shown in animal studies to have positive cardiac effects irrespective of its effects on glucose control and weight loss. This review discusses the biology of GLP-1 and its effects on cardiovascular risk factors, and it also elaborates on the positive direct cardiovascular outcomes of GLP-1 in animal studies.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalCurrent atherosclerosis reports
Volume11
Issue number2
DOIs
StatePublished - Mar 2 2009

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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