Glomerular lysosomal enzymes in aminonucleoside nephrosis

J. A. Velosa, S. V. Shah, S. L. Ou, H. E. Abboud, T. P. Dousa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Lysosomal hydrolases produce degradation of glomerular basement membrane and may play a key role in catabolism of glycoproteins of extracellular matrix in glomeruli. Therefore we investigated activities of some lysosomal enzymes and stability of lysosomes in glomeruli of normal and nephrotic rats. Nephrosis was induced in rats by single injections of puromycin aminonucleoside. In glomeruli from nephrotic rats we found lower activities of β-fucosidase and arylsulfatase, but activity of acid phosphatase was higher compared with control rats. Osmotic stability of lysosomes measured by release of β-glucuronidase was decreased in nephrotic rats. Abnormal activity of lysosomal enzymes and altered physiology of lysosomes in glomeruli may be a pathogenic factor in the altered glycoprotein metabolism in nephrotic syndrome and perhaps also in other glomerular diseases.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalRenal Physiology
Volume3
Issue number1-6
StatePublished - 1980
Externally publishedYes

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Puromycin Aminonucleoside
Nephrosis
Lysosomes
Enzymes
Glycoproteins
alpha-L-Fucosidase
Arylsulfatases
Enzyme Stability
Glomerular Basement Membrane
Glucuronidase
Nephrotic Syndrome
Hydrolases
Acid Phosphatase
Extracellular Matrix
Injections

ASJC Scopus subject areas

  • Physiology
  • Nephrology

Cite this

Velosa, J. A., Shah, S. V., Ou, S. L., Abboud, H. E., & Dousa, T. P. (1980). Glomerular lysosomal enzymes in aminonucleoside nephrosis. Renal Physiology, 3(1-6), 120-125.

Glomerular lysosomal enzymes in aminonucleoside nephrosis. / Velosa, J. A.; Shah, S. V.; Ou, S. L.; Abboud, H. E.; Dousa, T. P.

In: Renal Physiology, Vol. 3, No. 1-6, 1980, p. 120-125.

Research output: Contribution to journalArticle

Velosa, JA, Shah, SV, Ou, SL, Abboud, HE & Dousa, TP 1980, 'Glomerular lysosomal enzymes in aminonucleoside nephrosis', Renal Physiology, vol. 3, no. 1-6, pp. 120-125.
Velosa JA, Shah SV, Ou SL, Abboud HE, Dousa TP. Glomerular lysosomal enzymes in aminonucleoside nephrosis. Renal Physiology. 1980;3(1-6):120-125.
Velosa, J. A. ; Shah, S. V. ; Ou, S. L. ; Abboud, H. E. ; Dousa, T. P. / Glomerular lysosomal enzymes in aminonucleoside nephrosis. In: Renal Physiology. 1980 ; Vol. 3, No. 1-6. pp. 120-125.
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