Glomerular epithelium: Structural alterations induced by polycations

M. W. Seiler, Manjeri A Venkatachalam, R. S. Cotran

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Perfusion of rat kidneys with the polycation protamine sulfate caused glomerular epithelial alterations resembling those observed in human and experimental nephrotic states. The changes included swelling, blunting, and flattening of epithelial foot processes, were accompanied by decreased stainability of glomerular anionic sites, and were largely reversed by subsequent perfusion with the polyanion heparin.

Original languageEnglish (US)
Pages (from-to)390-393
Number of pages4
JournalScience
Volume189
Issue number4200
StatePublished - 1975
Externally publishedYes

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Epithelium
Perfusion
Protamines
Heparin
Foot
Kidney
polycations
polyanions

ASJC Scopus subject areas

  • General

Cite this

Glomerular epithelium : Structural alterations induced by polycations. / Seiler, M. W.; Venkatachalam, Manjeri A; Cotran, R. S.

In: Science, Vol. 189, No. 4200, 1975, p. 390-393.

Research output: Contribution to journalArticle

Seiler, MW, Venkatachalam, MA & Cotran, RS 1975, 'Glomerular epithelium: Structural alterations induced by polycations', Science, vol. 189, no. 4200, pp. 390-393.
Seiler, M. W. ; Venkatachalam, Manjeri A ; Cotran, R. S. / Glomerular epithelium : Structural alterations induced by polycations. In: Science. 1975 ; Vol. 189, No. 4200. pp. 390-393.
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