Global signatures of protein and mRNA expression levels

Raquel De Sousa Abreu, Luiz O. Penalva, Edward M. Marcotte, Christine Vogel

Research output: Contribution to journalReview articlepeer-review

980 Scopus citations


Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

Original languageEnglish (US)
Pages (from-to)1512-1526
Number of pages15
JournalMolecular BioSystems
Issue number12
StatePublished - 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Biotechnology


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