Getting on target: The archaeal signal recognition particle

Christian Zwieb, Jerry Eichler

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Protein translocation begins with the efficient targeting of secreted and membrane proteins to complexes embedded within the membrane. In Eukarya and Bacteria, this is achieved through the interaction of the signal recognition particle (SRP) with the nascent polypeptide chain. In Archaea, homologs of eukaryal and bacterial SRP-mediated translocation pathway components have been identified. Biochemical analysis has revealed that although the archaeal system incorporates various facets of the eukaryal and bacterial targeting systems, numerous aspects of the archaeal system are unique to this domain of life. Moreover, it is becoming increasingly clear that elucidation of the archaeal SRP pathway will provide answers to basic questions about protein targeting that cannot be obtained from examination of eukaryal or bacterial models. In this review, recent data regarding the molecular composition, functional behavior and evolutionary significance of the archaeal signal recognition particle pathway are discussed.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalArchaea
Volume1
Issue number1
DOIs
StatePublished - Mar 2002

Keywords

  • Protein targeting
  • Protein translocation
  • RNA
  • Ribonucleoprotein complex
  • Signal sequence

ASJC Scopus subject areas

  • Microbiology
  • Physiology
  • Ecology, Evolution, Behavior and Systematics

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