Genotype by energy expenditure interaction with metabolic syndrome traits: The Portuguese Healthy Family study

Daniel M V Santos, Peter T. Katzmarzyk, Vincent P. Diego, Michele C. Souza, Raquel N. Chaves, John Blangero, José A R Maia

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Moderate-to-high levels of physical activity are established as preventive factors in metabolic syndrome development. However, there is variability in the phenotypic expression of metabolic syndrome under distinct physical activity conditions. In the present study we applied a Genotype X Environment interaction method to examine the presence of GxEE interaction in the phenotypic expression of metabolic syndrome. A total of 958 subjects, from 294 families of The Portuguese Healthy Family study , were included in the analysis. Total daily energy expenditure was assessed using a 3 day physical activity diary. Six metabolic syndrome related traits, including waist circumference, systolic blood pressure, glucose, HDL cholesterol, total cholesterol and triglycerides, were measured and adjusted for age and sex. GxEE examination was performed on SOLAR 4.3.1. All metabolic syndrome indicators were significantly heritable. The GxEE interaction model fitted the data better than the polygenic model (p<0.001) for waist circumference, systolic blood pressure, glucose, total cholesterol and triglycerides. For waist circumference, glucose, total cholesterol and triglycerides, the significant GxEE interaction was due to rejection of the variance homogeneity hypothesis. For waist circumference and glucose, GxEE was also significant by the rejection of the genetic correlation hypothesis. The results showed that metabolic syndrome traits expression is significantly influenced by the interaction established between total daily energy expenditure and genotypes. Physical activity may be considered an environmental variable that promotes metabolic differences between individuals that are distinctively active.

Original languageEnglish (US)
Article numbere80417
JournalPLoS One
Volume8
Issue number11
DOIs
StatePublished - Nov 18 2013
Externally publishedYes

Fingerprint

family studies
metabolic syndrome
energy expenditure
Energy Metabolism
waist circumference
Genotype
Waist Circumference
Glucose
physical activity
Triglycerides
genotype
Cholesterol
Blood pressure
Blood Pressure
glucose
triacylglycerols
cholesterol
systolic blood pressure
Blood Glucose
HDL Cholesterol

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Santos, D. M. V., Katzmarzyk, P. T., Diego, V. P., Souza, M. C., Chaves, R. N., Blangero, J., & Maia, J. A. R. (2013). Genotype by energy expenditure interaction with metabolic syndrome traits: The Portuguese Healthy Family study. PLoS One, 8(11), [e80417]. https://doi.org/10.1371/journal.pone.0080417

Genotype by energy expenditure interaction with metabolic syndrome traits : The Portuguese Healthy Family study. / Santos, Daniel M V; Katzmarzyk, Peter T.; Diego, Vincent P.; Souza, Michele C.; Chaves, Raquel N.; Blangero, John; Maia, José A R.

In: PLoS One, Vol. 8, No. 11, e80417, 18.11.2013.

Research output: Contribution to journalArticle

Santos, DMV, Katzmarzyk, PT, Diego, VP, Souza, MC, Chaves, RN, Blangero, J & Maia, JAR 2013, 'Genotype by energy expenditure interaction with metabolic syndrome traits: The Portuguese Healthy Family study', PLoS One, vol. 8, no. 11, e80417. https://doi.org/10.1371/journal.pone.0080417
Santos, Daniel M V ; Katzmarzyk, Peter T. ; Diego, Vincent P. ; Souza, Michele C. ; Chaves, Raquel N. ; Blangero, John ; Maia, José A R. / Genotype by energy expenditure interaction with metabolic syndrome traits : The Portuguese Healthy Family study. In: PLoS One. 2013 ; Vol. 8, No. 11.
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