Genotype by energy expenditure interaction and body composition traits

The Portuguese healthy family study

D. M. Santos, P. T. Katzmarzyk, V. P. Diego, T. N. Gomes, F. K. Santos, J. Blangero, J. A. Maia

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and Aims. Energy expenditure has been negatively correlated with fat accumulation. However, this association is highly variable. In the present study we applied a genotype by environment interaction method to examine the presence of Genotype x by Total Daily Energy Expenditure and Genotype x by Daily Energy Expenditure interactions in the expression of different body composition traits. Methods and Results. A total of 958 subjects from 294 families of The Portuguese Healthy Family Study were included in the analysis. TDEE and DEE were assessed using a physical activity recall. Body fat percentages were measured with a bioelectrical impedance scale. GxTDEE and GxDEE examinations were performed using SOLAR 4.0 software. All BC traits were significantly heritable, with heritabilities ranging from 21% to 34%. The GxTDEE and GxDEE interaction models fitted the data better than the polygenic model for all traits. For all traits, a significant GxTDEE and GxDEE interaction was due to variance heterogeneity among distinct levels of TDEE and DEE. For WC, GxTDEE was also significant due to the genetic correlation function. Conclusions. TDEE and DEE are environmental constraints associated with the expression of individuals' BC genotypes, leading to variability in the phenotypic expression of BC traits.

Original languageEnglish (US)
Article number845207
JournalBioMed Research International
Volume2014
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Body Composition
Energy Metabolism
Genotype
Chemical analysis
Fats
Acoustic impedance
Electric Impedance
Association reactions
Adipose Tissue
Software

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Santos, D. M., Katzmarzyk, P. T., Diego, V. P., Gomes, T. N., Santos, F. K., Blangero, J., & Maia, J. A. (2014). Genotype by energy expenditure interaction and body composition traits: The Portuguese healthy family study. BioMed Research International, 2014, [845207]. https://doi.org/10.1155/2014/845207

Genotype by energy expenditure interaction and body composition traits : The Portuguese healthy family study. / Santos, D. M.; Katzmarzyk, P. T.; Diego, V. P.; Gomes, T. N.; Santos, F. K.; Blangero, J.; Maia, J. A.

In: BioMed Research International, Vol. 2014, 845207, 2014.

Research output: Contribution to journalArticle

Santos, DM, Katzmarzyk, PT, Diego, VP, Gomes, TN, Santos, FK, Blangero, J & Maia, JA 2014, 'Genotype by energy expenditure interaction and body composition traits: The Portuguese healthy family study', BioMed Research International, vol. 2014, 845207. https://doi.org/10.1155/2014/845207
Santos, D. M. ; Katzmarzyk, P. T. ; Diego, V. P. ; Gomes, T. N. ; Santos, F. K. ; Blangero, J. ; Maia, J. A. / Genotype by energy expenditure interaction and body composition traits : The Portuguese healthy family study. In: BioMed Research International. 2014 ; Vol. 2014.
@article{dcfd3bff785b4efcbec5ba7725792b44,
title = "Genotype by energy expenditure interaction and body composition traits: The Portuguese healthy family study",
abstract = "Background and Aims. Energy expenditure has been negatively correlated with fat accumulation. However, this association is highly variable. In the present study we applied a genotype by environment interaction method to examine the presence of Genotype x by Total Daily Energy Expenditure and Genotype x by Daily Energy Expenditure interactions in the expression of different body composition traits. Methods and Results. A total of 958 subjects from 294 families of The Portuguese Healthy Family Study were included in the analysis. TDEE and DEE were assessed using a physical activity recall. Body fat percentages were measured with a bioelectrical impedance scale. GxTDEE and GxDEE examinations were performed using SOLAR 4.0 software. All BC traits were significantly heritable, with heritabilities ranging from 21{\%} to 34{\%}. The GxTDEE and GxDEE interaction models fitted the data better than the polygenic model for all traits. For all traits, a significant GxTDEE and GxDEE interaction was due to variance heterogeneity among distinct levels of TDEE and DEE. For WC, GxTDEE was also significant due to the genetic correlation function. Conclusions. TDEE and DEE are environmental constraints associated with the expression of individuals' BC genotypes, leading to variability in the phenotypic expression of BC traits.",
author = "Santos, {D. M.} and Katzmarzyk, {P. T.} and Diego, {V. P.} and Gomes, {T. N.} and Santos, {F. K.} and J. Blangero and Maia, {J. A.}",
year = "2014",
doi = "10.1155/2014/845207",
language = "English (US)",
volume = "2014",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Genotype by energy expenditure interaction and body composition traits

T2 - The Portuguese healthy family study

AU - Santos, D. M.

AU - Katzmarzyk, P. T.

AU - Diego, V. P.

AU - Gomes, T. N.

AU - Santos, F. K.

AU - Blangero, J.

AU - Maia, J. A.

PY - 2014

Y1 - 2014

N2 - Background and Aims. Energy expenditure has been negatively correlated with fat accumulation. However, this association is highly variable. In the present study we applied a genotype by environment interaction method to examine the presence of Genotype x by Total Daily Energy Expenditure and Genotype x by Daily Energy Expenditure interactions in the expression of different body composition traits. Methods and Results. A total of 958 subjects from 294 families of The Portuguese Healthy Family Study were included in the analysis. TDEE and DEE were assessed using a physical activity recall. Body fat percentages were measured with a bioelectrical impedance scale. GxTDEE and GxDEE examinations were performed using SOLAR 4.0 software. All BC traits were significantly heritable, with heritabilities ranging from 21% to 34%. The GxTDEE and GxDEE interaction models fitted the data better than the polygenic model for all traits. For all traits, a significant GxTDEE and GxDEE interaction was due to variance heterogeneity among distinct levels of TDEE and DEE. For WC, GxTDEE was also significant due to the genetic correlation function. Conclusions. TDEE and DEE are environmental constraints associated with the expression of individuals' BC genotypes, leading to variability in the phenotypic expression of BC traits.

AB - Background and Aims. Energy expenditure has been negatively correlated with fat accumulation. However, this association is highly variable. In the present study we applied a genotype by environment interaction method to examine the presence of Genotype x by Total Daily Energy Expenditure and Genotype x by Daily Energy Expenditure interactions in the expression of different body composition traits. Methods and Results. A total of 958 subjects from 294 families of The Portuguese Healthy Family Study were included in the analysis. TDEE and DEE were assessed using a physical activity recall. Body fat percentages were measured with a bioelectrical impedance scale. GxTDEE and GxDEE examinations were performed using SOLAR 4.0 software. All BC traits were significantly heritable, with heritabilities ranging from 21% to 34%. The GxTDEE and GxDEE interaction models fitted the data better than the polygenic model for all traits. For all traits, a significant GxTDEE and GxDEE interaction was due to variance heterogeneity among distinct levels of TDEE and DEE. For WC, GxTDEE was also significant due to the genetic correlation function. Conclusions. TDEE and DEE are environmental constraints associated with the expression of individuals' BC genotypes, leading to variability in the phenotypic expression of BC traits.

UR - http://www.scopus.com/inward/record.url?scp=84899562938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899562938&partnerID=8YFLogxK

U2 - 10.1155/2014/845207

DO - 10.1155/2014/845207

M3 - Article

VL - 2014

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 845207

ER -