Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans

Sobha Puppala, Rector Arya, Farook Thameem, Nedal H. Arar, Kusum Bhandari, Donna M. Lehman, Jennifer Schneider, Sharon Fowler, Vidya S. Farook, Vincent P. Diego, Laura Almasy, John Blangero, Michael P. Stern, Ravindranath Duggirala, Hanna E. Abboud

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

OBJECTIVE - Glomerular filtration rate (GFR) is used to assess the progression of renal disease. We performed linkage analysis to localize genes that influence GFR using estimated GFR data from the San Antonio Family Diabetes/Gallbladder Study. We also examined the effect of genotype by diabetes interaction (G X DM) on the detection of linkage to address whether genetic effects on GFR differ in diabetic and nondiabetic subjects. RESEARCH DESIGN AND METHODS - GFR (N = 453) was estimated using the recently recalculated Cockcroft-Gault (GFR-CGc) and the simplified Modification of Diet in Renal Disease (GFR-4VMDRD) formulae. Both estimates of GFR exhibited significant heritabilities, but only GFR-CGc showed significant G X DM interaction. We therefore performed multipoint linkage analyses on both GFR measures using models that did not include G X DM interaction effects (Model 1) and that included G X DM interaction effects (Model 2, in the case of GFR-CGc). RESULTS - The strongest evidence for linkage (Model 1) of both GFR-CGc (logarithm of odds [LOD] 2.9) and GFR-4VMDRD (LOD 2.6) occurred between markers D9S922 and D9S1120 on chromosome 9q. However, using Model 2, the strongest evidence for linkage of GFR-CGc on chromosome 2q was found near marker D2S427 (corrected LOD score [LODC] 3.3) compared with the LOD score of 2.7 based on Model 1. Potential linkages (LOD or LODC ≥1.2) were found only for GFR-CGc on chromosomes 3p, 3q, 4p, 8q, 11q, and 14q. CONCLUSIONS - We found a major locus on chromosome 2q that differentially influences GFR in diabetic and nondiabetic environments in the Mexican-American population.

Original languageEnglish (US)
Pages (from-to)2818-2828
Number of pages11
JournalDiabetes
Volume56
Issue number11
DOIs
StatePublished - Nov 2007

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans'. Together they form a unique fingerprint.

Cite this