TY - JOUR
T1 - Genomics and Proteomics in Predicting Cancer Outcomes
AU - Parikh, Alexander A.
AU - Johnson, J. Chad
AU - Merchant, Nipun B.
PY - 2008/4
Y1 - 2008/4
N2 - Sequencing of the human genome and the acquisition of genomic data combined with advances in genomic and proteomic technologies have fueled a revolution in understanding disease. The combination of genomics and proteomics has provided a unique opportunity to diagnose, classify, and detect malignant disease, to better understand and define the behavior of specific tumors, and to provide direct and targeted therapy. Nevertheless, challenges remain, including integration and standardization of techniques and validation against accepted clinical and pathologic parameters. This article provides a summary of technologies, potential clinical applications, and challenges.
AB - Sequencing of the human genome and the acquisition of genomic data combined with advances in genomic and proteomic technologies have fueled a revolution in understanding disease. The combination of genomics and proteomics has provided a unique opportunity to diagnose, classify, and detect malignant disease, to better understand and define the behavior of specific tumors, and to provide direct and targeted therapy. Nevertheless, challenges remain, including integration and standardization of techniques and validation against accepted clinical and pathologic parameters. This article provides a summary of technologies, potential clinical applications, and challenges.
UR - http://www.scopus.com/inward/record.url?scp=41049084986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41049084986&partnerID=8YFLogxK
U2 - 10.1016/j.soc.2007.12.001
DO - 10.1016/j.soc.2007.12.001
M3 - Review article
C2 - 18375352
AN - SCOPUS:41049084986
SN - 1055-3207
VL - 17
SP - 257
EP - 277
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
IS - 2
ER -