Genomic studies of human populations

Resequencing approaches to the identification of human quantitative loci

Joanne E. Curran, Claire Bellis, Laura Almasy, John Blangero

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.

Original languageEnglish (US)
Title of host publicationGenome Mapping and Genomics in Human and Non-Human Primates
PublisherSpringer Berlin Heidelberg
Pages289-299
Number of pages11
ISBN (Print)9783662463062, 9783662463055
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Forensic Anthropology
human population
pedigree
sequence analysis
experimental design
RNA Sequence Analysis
genomics
loci
genome
Pedigree
Population
Genes
Genome
RNA

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Curran, J. E., Bellis, C., Almasy, L., & Blangero, J. (2015). Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci. In Genome Mapping and Genomics in Human and Non-Human Primates (pp. 289-299). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-46306-2_16

Genomic studies of human populations : Resequencing approaches to the identification of human quantitative loci. / Curran, Joanne E.; Bellis, Claire; Almasy, Laura; Blangero, John.

Genome Mapping and Genomics in Human and Non-Human Primates. Springer Berlin Heidelberg, 2015. p. 289-299.

Research output: Chapter in Book/Report/Conference proceedingChapter

Curran, JE, Bellis, C, Almasy, L & Blangero, J 2015, Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci. in Genome Mapping and Genomics in Human and Non-Human Primates. Springer Berlin Heidelberg, pp. 289-299. https://doi.org/10.1007/978-3-662-46306-2_16
Curran JE, Bellis C, Almasy L, Blangero J. Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci. In Genome Mapping and Genomics in Human and Non-Human Primates. Springer Berlin Heidelberg. 2015. p. 289-299 https://doi.org/10.1007/978-3-662-46306-2_16
Curran, Joanne E. ; Bellis, Claire ; Almasy, Laura ; Blangero, John. / Genomic studies of human populations : Resequencing approaches to the identification of human quantitative loci. Genome Mapping and Genomics in Human and Non-Human Primates. Springer Berlin Heidelberg, 2015. pp. 289-299
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