Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci

Joanne E. Curran, Claire Bellis, Laura Almasy, John Blangero

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.

Original languageEnglish (US)
Title of host publicationGenome Mapping and Genomics in Human and Non-Human Primates
PublisherSpringer Berlin Heidelberg
Pages289-299
Number of pages11
ISBN (Print)9783662463062, 9783662463055
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci'. Together they form a unique fingerprint.

Cite this