Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci

Joanne E. Curran; Claire Bellis; Laura Almasy; John Blangero

doi:10.1007/978-3-662-46306-2_16

Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci

Joanne E. Curran, Claire Bellis, Laura Almasy, John Blangero

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.

Original language	English (US)
Title of host publication	Genome Mapping and Genomics in Human and Non-Human Primates
Publisher	Springer Berlin Heidelberg
Pages	289-299
Number of pages	11
ISBN (Print)	9783662463062, 9783662463055
DOIs	https://doi.org/10.1007/978-3-662-46306-2_16
State	Published - Jan 1 2015
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-3-662-46306-2_16

Cite this

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AU - Blangero, John

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AB - In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.

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BT - Genome Mapping and Genomics in Human and Non-Human Primates

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ER -

Genomic studies of human populations: Resequencing approaches to the identification of human quantitative loci

Abstract

ASJC Scopus subject areas

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