Abstract
In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.
| Original language | English (US) |
|---|---|
| Title of host publication | Genome Mapping and Genomics in Human and Non-Human Primates |
| Publisher | Springer Berlin Heidelberg |
| Pages | 289-299 |
| Number of pages | 11 |
| ISBN (Print) | 9783662463062, 9783662463055 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Genomic studies of human populations : Resequencing approaches to the identification of human quantitative loci. / Curran, Joanne E.; Bellis, Claire; Almasy, Laura; Blangero, John.
Genome Mapping and Genomics in Human and Non-Human Primates. Springer Berlin Heidelberg, 2015. p. 289-299.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Genomic studies of human populations
T2 - Resequencing approaches to the identification of human quantitative loci
AU - Curran, Joanne E.
AU - Bellis, Claire
AU - Almasy, Laura
AU - Blangero, John
PY - 2015/1/1
Y1 - 2015/1/1
N2 - In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.
AB - In this chapter, we explore resequencing approaches to identify the quantitative loci in human populations. We will discuss why sequencing studies are optimal for variant discovery for common complex disease and how we go about localizing and identifying these causal variants. There are several different sequencing applications available to us today ranging from RNA sequencing to targeted genomic sequencing and extending to whole genome sequencing. We explore each of these applications and their individual utilities. Further, we explore studies of complex pedigrees compared to unrelated individuals, the two most common study designs used for human complex disease.
UR - http://www.scopus.com/inward/record.url?scp=84944608071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944608071&partnerID=8YFLogxK
U2 - 10.1007/978-3-662-46306-2_16
DO - 10.1007/978-3-662-46306-2_16
M3 - Chapter
SN - 9783662463062
SN - 9783662463055
SP - 289
EP - 299
BT - Genome Mapping and Genomics in Human and Non-Human Primates
PB - Springer Berlin Heidelberg
ER -