Genomic strategies for diabetic nephropathy

Katalin Susztak, Kumar Sharma, Mario Schiffer, Peter McCue, Emilio Ciccone, Erwin P. Böttinger

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Insight into the molecular mechanisms that underlie the origin and progression of diabetic nephropathy remains limited in part because conventional research tools have restricted investigators to focus on single genes or isolated pathways. Microarray technologies provide opportunities for evaluating genetic factors and environmental effects at a genomic scale during the pathogenesis of diabetic nephropathy. Despite the enormous power of the microarray technology, there are several pitfalls that need to be considered. This article discusses conceptual, practical, statistical, and logistical considerations for the use of microarrays in studies of experimental and human diabetic renal disease. New knowledge in this field will facilitate new approaches for molecular diagnosis and drug discovery.

Original languageEnglish (US)
Pages (from-to)S271-S278
JournalJournal of the American Society of Nephrology
Volume14
Issue numberSUPPL. 3
StatePublished - Aug 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

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