Abstract
Our laboratory has determined the DNA sequence and transcriptional expression pattern of a mouse cDNA clone termed Nma/BAMBI. This clone encodes a highly conserved protein with 89% identity to the human homologue (termed Nma) and 78% similarity to the Xenopus homologue (termed BAMBI) at the predicted amino acid level. Nma/BAMBI encodes a 260-amino-acid transmembrane protein that has homology to the transforming growth factor (TGF) β type I receptor family. This protein contains an extracellular ligand binding domain, a 24-amino-acid transmembrane domain, and a short intracellular domain that lacks a functional serine/threonine kinase domain. It is believed that Nma/BAMBI is important in the negative regulation of TGFβ signal transduction pathways during development and has implications in tumor progression. We have determined the genomic organization of the mouse Nma/BAMBI gene and confirmed the chromosomal mapping to human chromosome 10 and mouse chromosome 2. Furthermore, we report the production and utilization of an anti-peptide antibody in preliminary immunohistochemical analysis of an ameloblastoma.
Original language | English (US) |
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Pages (from-to) | 359-364 |
Number of pages | 6 |
Journal | Connective Tissue Research |
Volume | 43 |
Issue number | 2-3 |
DOIs | |
State | Published - 2002 |
Keywords
- Ameloblastoma
- Bone morphogenic protein and activin membrane bound inhibitor (BAMBI)
- Chromosome 10
- Nonmetastatic gene A (Nma)
- TGFβ type I receptor
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Rheumatology
- Cell Biology
- Orthopedics and Sports Medicine