Abstract
Jiang et al. characterize primary Chinese triple-negative breast cancer (TNBC) and classify it into four subtypes. They find that these TNBCs have more frequent PIK3CA mutations and chromosome 22q11 copy-number gains than non-Asian TNBCs and that the LAR subtype has more ERBB2 somatic mutations and CDKN2A loss.
Original language | English (US) |
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Pages (from-to) | 428-440.e5 |
Journal | Cancer Cell |
Volume | 35 |
Issue number | 3 |
DOIs | |
State | Published - Mar 18 2019 |
Keywords
- genomic
- molecular subtype
- precision therapies
- target
- transcriptomic
- triple-negative breast cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research