Genome-wide search for genes affecting the risk for alcohol dependence

Theodore Reich, Howard J. Edenberg, Alison Goate, Jeff T. Williams, John P. Rice, Paul Van Eerdewegh, Tatiana Foroud, Victor Hesselbrock, Marc A. Schuckit, Kathleen Bucholz, Bernice Porjesz, Ting Kai Li, P. Michael Conneally, John I. Nurnberger, Jay A. Tischfield, Raymond R. Crowe, C. Robert Cloninger, William Wu, Shantia Shears, Kristie CarrCandice Crose, Chris Willig, Henri Begleiter

    Research output: Contribution to journalArticlepeer-review

    614 Scopus citations


    Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are reported by contemporary studies of twins. We report on the results of a six- center collaborative study to identify susceptibility loci for alcohol dependence. A genome-wide screen examined 291 markers in 987 individuals from 105 families. Two-point and multipoint nonparametric linkage analyses were performed to detect susceptibility loci for alcohol dependence. Multipoint methods provided the strongest suggestions of linkage with susceptibility loci for alcohol dependence on chromosomes 1 and 7, and more modest evidence for a locus on chromosome 2. In addition, there was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.

    Original languageEnglish (US)
    Pages (from-to)207-215
    Number of pages9
    JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
    Issue number3
    StatePublished - May 8 1998


    • Alcohol dependence
    • Alcoholism
    • Genetic susceptibility
    • Genome screening
    • Linkage analysis

    ASJC Scopus subject areas

    • Genetics(clinical)
    • Psychiatry and Mental health
    • Cellular and Molecular Neuroscience


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