Genome-wide scans for microalbuminuria in Mexican Americans: The San Antonio Family Heart Study

Nedal Arar, Subrata Nath, Farook Thameem, Richard Bauer, Saroja Voruganti, Anthony Comuzzie, Shelley Cole, John Blangero, Jean MacCluer, Hanna Abboud

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

PURPOSE: Microalbuminuria, defined as urine albumin-to-creatinine ratio of 0.03 to 0.299 mg/mg, is a major risk factor for cardiovascular disease. Several genetic epidemiological studies have established that microalbuminuria clusters in families, suggesting a genetic predisposition. METHOD: We estimated heritability of microalbuminuria and performed a genome-wide linkage analysis to identify chromosomal regions influencing urine albumin-to-creatinine ratio in 486 Mexican Americans from 26 multiplex families. RESULTS: Significant heritability was demonstrated for urine albumin-to-creatinine ratio (h = 24%, P < 0.003) after accounting for age, sex, body mass index, triglycerides, and hypertension. Genome scan revealed significant evidence of linkage of urine albumin-to-creatinine ratio to a region on chromosome 20q12 (LOD score of 3.5, P < 0.001) near marker D20S481. This region also exhibited a LOD score of 2.8 with diabetes status as a covariate and 3.0 with hypertension status as a covariate suggesting that the effect of this locus on urine albumin-to- creatinine ratio is largely independent of diabetes and hypertension. CONCLUSION: Findings indicate that there is a gene or genes located on human chromosome 20q12 that may have functional relevance to albumin excretion in Mexican Americans. Identifying and understanding the role of the genes that determine albumin excretion would lead to the development of novel therapeutic strategies targeted at high-risk individuals in whom intensive preventive measures may be most beneficial.

Original languageEnglish (US)
Pages (from-to)80-87
Number of pages8
JournalGenetics in Medicine
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2007

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Keywords

  • Albumin to creatinine ratio
  • Cardiovascular diseases
  • Family genetic study
  • Mexican Americans
  • Microalbuminuria

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Arar, N., Nath, S., Thameem, F., Bauer, R., Voruganti, S., Comuzzie, A., Cole, S., Blangero, J., MacCluer, J., & Abboud, H. (2007). Genome-wide scans for microalbuminuria in Mexican Americans: The San Antonio Family Heart Study. Genetics in Medicine, 9(2), 80-87. https://doi.org/10.1097/GIM.0b013e31803068ec