Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Sudha K. Iyengar, Hanna E. Abboud, Katrina A.B. Goddard, Mohammed F. Saad, Sharon G. Adler, Nedal H. Arar, Donald W. Bowden, Ravi Duggirala, Robert C. Elston, Robert L. Hanson, Eli Ipp, W. H.Linda Kao, Paul L. Kimmel, Michael J. Klag, William C. Knowler, Lucy A. Meoni, Robert G. Nelson, Susanne B. Nicholas, Madeleine V. Pahl, Rulan S. ParekhShannon R.E. Quade, Stephen S. Rich, Jerome I. Rotter, Marina Scavini, Jeffrey R. Schelling, John R. Sedor, Ashwini R. Sehgal, Vallabh O. Shah, Michael W. Smith, Kent D. Taylor, Cheryl A. Winkler, Philip G. Zager, Barry I. Freedman

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

The Family Investigation of Nephropathy and Diabetes (FIND) was initiated to map genes underlying susceptibility to diabetic nephropathy. A total of 11 centers participated under a single collection protocol to recruit large numbers of diabetic sibling pairs concordant and discordant for diabetic nephropathy. We report the findings from the first-phase genetic analyses in 1,227 participants from 378 pedigrees of European-American, African-American, Mexican-American, and American Indian descent recruited from eight centers. Model-free linkage analyses, using a dichotomous definition for diabetic nephropathy in 397 sibling pairs, as well as the quantitative trait urinary albumin-to-creatinine ratio (ACR), were performed using the Haseman-Elston linkage test on 404 microsatellite markers. The strongest evidence of linkage to the diabetic nephropathy trait was on chromosomes 7q21.3, 10p15.3, 14q23.1, and 18q22.3. In ACR (883 diabetic sibling pairs), the strongest linkage signals were on chromosomes 2q14.1, 7q21.1, and 15q26.3. These results confirm regions of linkage to diabetic nephropathy on chromosomes 7q, 10p, and 18q from prior reports, making it important that genes underlying these peaks be evaluated for their contribution to nephropathy susceptibility. Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes.

Original languageEnglish (US)
Pages (from-to)1577-1585
Number of pages9
JournalDiabetes
Volume56
Issue number6
DOIs
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Iyengar, S. K., Abboud, H. E., Goddard, K. A. B., Saad, M. F., Adler, S. G., Arar, N. H., Bowden, D. W., Duggirala, R., Elston, R. C., Hanson, R. L., Ipp, E., Kao, W. H. L., Kimmel, P. L., Klag, M. J., Knowler, W. C., Meoni, L. A., Nelson, R. G., Nicholas, S. B., Pahl, M. V., ... Freedman, B. I. (2007). Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND). Diabetes, 56(6), 1577-1585. https://doi.org/10.2337/db06-1154