Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

AMFS Investigators, ATHENS Melanoma Study Group, GenoMEL Consortium, Essen-Heidelberg Investigators, The SDH Study Group, Q-MEGA and QTWIN Investigators

    Research output: Contribution to journalArticle

    122 Scopus citations

    Abstract

    Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10-8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.

    Original languageEnglish (US)
    Pages (from-to)987-995
    Number of pages9
    JournalNature Genetics
    Volume47
    Issue number9
    DOIs
    StatePublished - Aug 27 2015

    ASJC Scopus subject areas

    • Genetics

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  • Cite this

    AMFS Investigators, ATHENS Melanoma Study Group, GenoMEL Consortium, Essen-Heidelberg Investigators, The SDH Study Group, & Q-MEGA and QTWIN Investigators (2015). Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature Genetics, 47(9), 987-995. https://doi.org/10.1038/ng.3373