Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Jari Lahti, Samuli Tuominen, Qiong Yang, Giulio Pergola, Shahzad Ahmad, Najaf Amin, Nicola J. Armstrong, Alexa Beiser, Katharina Bey, Joshua C. Bis, Eric Boerwinkle, Jan Bressler, Archie Campbell, Harry Campbell, Qiang Chen, Janie Corley, Simon R. Cox, Gail Davies, Philip L. De Jager, Eske M. DerksJessica D. Faul, Annette L. Fitzpatrick, Alison E. Fohner, Ian Ford, Myriam Fornage, Zachary Gerring, Hans J. Grabe, Francine Grodstein, Vilmundur Gudnason, Eleanor Simonsick, Elizabeth G. Holliday, Peter K. Joshi, Eero Kajantie, Jaakko Kaprio, Pauliina Karell, Luca Kleineidam, Maria J. Knol, Nicole A. Kochan, John B. Kwok, Markus Leber, Max Lam, Teresa Lee, Shuo Li, Anu Loukola, Tobias Luck, Riccardo E. Marioni, Karen A. Mather, Sarah Medland, Saira S. Mirza, Mike A. Nalls, Kwangsik Nho, Adrienne O’Donnell, Christopher Oldmeadow, Jodie Painter, Alison Pattie, Simone Reppermund, Shannon L. Risacher, Richard J. Rose, Vijay Sadashivaiah, Markus Scholz, Claudia L. Satizabal, Peter W. Schofield, Katharina E. Schraut, Rodney J. Scott, Jeannette Simino, Albert V. Smith, Jennifer A. Smith, David J. Stott, Ida Surakka, Alexander Teumer, Anbupalam Thalamuthu, Stella Trompet, Stephen T. Turner, Sven J. van der Lee, Arno Villringer, Uwe Völker, Robert S. Wilson, Katharina Wittfeld, Eero Vuoksimaa, Rui Xia, Kristine Yaffe, Lei Yu, Habil Zare, Wei Zhao, David Ames, John Attia, David A. Bennett, Henry Brodaty, Daniel I. Chasman, Aaron L. Goldman, Caroline Hayward, M. Arfan Ikram, J. Wouter Jukema, Sharon L.R. Kardia, Todd Lencz, Markus Loeffler, Venkata S. Mattay, Aarno Palotie, Bruce M. Psaty, Alfredo Ramirez, Paul M. Ridker, Steffi G. Riedel-Heller, Perminder S. Sachdev, Andrew J. Saykin, Martin Scherer, Peter R. Schofield, Stephen Sidney, John M. Starr, Julian Trollor, William Ulrich, Michael Wagner, David R. Weir, James F. Wilson, Margaret J. Wright, Daniel R. Weinberger, Stephanie Debette, Johan G. Eriksson, Thomas H. Mosley, Lenore J. Launer, Cornelia M. van Duijn, Ian J. Deary, Sudha Seshadri, Katri Räikkönen

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Original languageEnglish (US)
Pages (from-to)4419-4431
Number of pages13
JournalMolecular psychiatry
Volume27
Issue number11
DOIs
StatePublished - Nov 2022

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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