Genome-wide linkage analysis of hemodynamic parameters under mental and physical stress in extended Omani Arab pedigrees: The Oman family study

Mohammed O. Hassan, Deepali Jaju, V. Saroja Voruganti, Riad A. Bayoumi, Sulayma Albarwani, Saeed Al-Yahyaee, Afshin Aslani, Harold Snieder, Juan C. Lopez-Alvarenga, Zahir M. Al-Anqoudi, Behrooz Z. Alizadeh, Anthony G. Comuzzie

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    Background: We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests. Methods: The Oman Family Study subjects (N = 1277) were recruited from five extended families of ∼10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (Δ), using variance components decomposition-based methods implemented in SOLAR. Results: Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventricular ejection time (LVET), respectively. For ΔWCT, suggestive QTLs were detected for CO on chr11 (LOD = 2.5), LVET on chr3 (LOD = 2.0) and EDI on chr9 (LOD = 2.1). For CPT, suggestive QTLs for HR and LVET shared the same region on chr22 (LOD 2.3 and 2.8, respectively) and on chr9 (LOD = 2.3) for SBP, chr7 (LOD = 2.4) for SV and chr19 (LOD = 2.6) for CO. For ΔCPT, CO and TPR top signals were detected on chr15 and 10 (LOD; 2.40, 2.08) respectively. Conclusion: Mental stress revealed the largest number of significant and suggestive loci for normal BP reported to date. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis of essential hypertension.

    Original languageEnglish (US)
    Pages (from-to)257-267
    Number of pages11
    JournalTwin Research and Human Genetics
    Volume14
    Issue number3
    DOIs
    StatePublished - Jun 2011

    Keywords

    • Arab pedigrees
    • Genome-wide
    • Haemodynamics
    • Linkage
    • Stress

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology
    • Genetics(clinical)

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