Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: The San Antonio Family Diabetes/Gallbladder Study

Kelly J. Hunt, Donna M. Lehman, Rector Arya, Sharon Fowler, Robin J. Leach, Harald H.H. Göring, Laura Almasy, John Blangero, Tom D. Dyer, Ravindranath Duggirala, Michael P. Stern

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The San Antonio Family Diabetes/Gallbladder Study was initiated to identify susceptibility genes for type 2 diabetes. Evidence was previously reported of linkage to diabetes on 10q with suggestive evidence on 3p and 9p in a genome-wide scan of 440 individuals from 27 pedigrees ascertained through a single diabetic proband. Subsequently, the study was expanded to include 906 individuals from 39 extended Mexican-American pedigrees, two additional examination cycles ∼5.3 and 7.6 years after baseline, and genotypes for a new set of genome-wide markers. Therefore, we completed a second genome-wide linkage scan. Using information from a participant's most recent exam, the prevalence of diabetes in nonprobands was 21.8%. We performed genome-wide variance components-based genetic analysis on the discrete trait diabetes using a liability model and on the quantitative Martingale residual obtained from modeling age of diabetes diagnosis using Cox proportional hazard models. Controlling for age and age, our strongest evidence for linkage to the trait diabetes and the quantitative Martingale residual was on chromosome 3p at marker D3S2406 with multipoint empirical logarithm of odds scores of 1.87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations.

Original languageEnglish (US)
Pages (from-to)2655-2662
Number of pages8
JournalDiabetes
Volume54
Issue number9
DOIs
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: The San Antonio Family Diabetes/Gallbladder Study'. Together they form a unique fingerprint.

Cite this