TY - JOUR
T1 - Genome-wide expression in veterans with schizophrenia further validates the immune hypothesis for schizophrenia
AU - Fries, Gabriel R.
AU - Dimitrov, Dimitre H.
AU - Lee, Shuko
AU - Braida, Nicole
AU - Yantis, Jesse
AU - Honaker, Craig
AU - Cuellar, Joe
AU - Walss-Bass, Consuelo
PY - 2017/1/13
Y1 - 2017/1/13
N2 - This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a genome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative loci were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia.
AB - This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a genome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative loci were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia.
KW - Cytokine
KW - Gene expression
KW - Inflammation
KW - Schizophrenia
KW - Veterans
UR - http://www.scopus.com/inward/record.url?scp=85020890818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020890818&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2017.06.016
DO - 10.1016/j.schres.2017.06.016
M3 - Article
AN - SCOPUS:85020890818
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -