Genome-wide expression in veterans with schizophrenia further validates the immune hypothesis for schizophrenia

Gabriel R. Fries, Dimitre H. Dimitrov, Shuko Lee, Nicole Braida, Jesse Yantis, Craig Honaker, Joe Cuellar, Consuelo Walss-Bass

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a genome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative loci were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia.

Original languageEnglish (US)
JournalSchizophrenia Research
DOIs
StateAccepted/In press - Jan 13 2017
Externally publishedYes

Keywords

  • Cytokine
  • Gene expression
  • Inflammation
  • Schizophrenia
  • Veterans

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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