Genome-wide expression in veterans with schizophrenia further validates the immune hypothesis for schizophrenia

Gabriel R. Fries; Dimitre H. Dimitrov; Shuko Lee; Nicole Braida; Jesse Yantis; Craig Honaker; Joe Cuellar; Consuelo Walss-Bass

doi:10.1016/j.schres.2017.06.016

Genome-wide expression in veterans with schizophrenia further validates the immune hypothesis for schizophrenia

Gabriel R. Fries, Dimitre H. Dimitrov, Shuko Lee, Nicole Braida, Jesse Yantis, Craig Honaker, Joe Cuellar, Consuelo Walss-Bass

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a genome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative loci were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia.

Original language	English (US)
Journal	Schizophrenia Research
DOIs	https://doi.org/10.1016/j.schres.2017.06.016
State	Accepted/In press - Jan 13 2017
Externally published	Yes

Keywords

Cytokine
Gene expression
Inflammation
Schizophrenia
Veterans

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2017.06.016

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title = "Genome-wide expression in veterans with schizophrenia further validates the immune hypothesis for schizophrenia",

abstract = "This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a genome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative loci were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia.",

keywords = "Cytokine, Gene expression, Inflammation, Schizophrenia, Veterans",

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doi = "10.1016/j.schres.2017.06.016",

language = "English (US)",

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T1 - Genome-wide expression in veterans with schizophrenia further validates the immune hypothesis for schizophrenia

AU - Fries, Gabriel R.

AU - Dimitrov, Dimitre H.

AU - Lee, Shuko

AU - Braida, Nicole

AU - Yantis, Jesse

AU - Honaker, Craig

AU - Cuellar, Joe

AU - Walss-Bass, Consuelo

PY - 2017/1/13

Y1 - 2017/1/13

N2 - This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a genome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative loci were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia.

AB - This study aimed to test whether a dysregulation of gene expression may be the underlying cause of previously reported elevated levels of inflammatory cytokines in veterans with schizophrenia. We performed a genome-wide expression analysis in peripheral blood mononuclear cells from veterans with schizophrenia and controls, and our results show that 167 genes and putative loci were differently expressed between groups. These genes were enriched primarily for pathways related to inflammatory mechanisms and formed networks related to cell death and survival, immune cell trafficking, among others, which is in line with previous reports and further validates the inflammatory hypothesis of schizophrenia.

KW - Cytokine

KW - Gene expression

KW - Inflammation

KW - Schizophrenia

KW - Veterans

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DO - 10.1016/j.schres.2017.06.016

M3 - Article

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JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

Genome-wide expression in veterans with schizophrenia further validates the immune hypothesis for schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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