Genome mining for human cancer genes: Wherefore art thou?

Thomas G. Boyer; Phang Lang Chen; Wen Hwa Lee

doi:10.1016/S1471-4914(01)01990-6

Genome mining for human cancer genes: Wherefore art thou?

Thomas G. Boyer, Phang Lang Chen, Wen Hwa Lee

Molecular Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

In an initial data-mining effort, the draft human genome was searched to find paralogs of known tumor suppressor genes, and for gene arrangements, which are typical of oncogenes, in cancer cells. The results were disappointing, indicating that although knowledge of the human genome will undoubtedly be of great help, other approaches to identify new oncogenes are needed.

Original language	English (US)
Pages (from-to)	187-189
Number of pages	3
Journal	Trends in Molecular Medicine
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/S1471-4914(01)01990-6
State	Published - 2001

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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title = "Genome mining for human cancer genes: Wherefore art thou?",

abstract = "In an initial data-mining effort, the draft human genome was searched to find paralogs of known tumor suppressor genes, and for gene arrangements, which are typical of oncogenes, in cancer cells. The results were disappointing, indicating that although knowledge of the human genome will undoubtedly be of great help, other approaches to identify new oncogenes are needed.",

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AB - In an initial data-mining effort, the draft human genome was searched to find paralogs of known tumor suppressor genes, and for gene arrangements, which are typical of oncogenes, in cancer cells. The results were disappointing, indicating that although knowledge of the human genome will undoubtedly be of great help, other approaches to identify new oncogenes are needed.

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Genome mining for human cancer genes: Wherefore art thou?

Abstract

ASJC Scopus subject areas

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