Genome mapping and genomics in human and non-human primates

Ravindranath Duggirala, Laura Almasy, Sarah Williams-Blangero, Solomon F.D. Paul, Chittaranjan Kole

    Research output: Book/ReportBook

    1 Scopus citations

    Abstract

    This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented. Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.

    Original languageEnglish (US)
    PublisherSpringer Berlin Heidelberg
    Number of pages305
    ISBN (Electronic)9783662463062
    ISBN (Print)9783662463055
    DOIs
    StatePublished - Jan 1 2015

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)

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