Genome and hormones: Gender differences in physiology selected contribution: Gender differences in the endothelin-B receptor contribution to basal cutaneous vascular tone in humans

D. L. Kellogg, Y. Liu, P. E. Pérgola

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

To test whether the contribution of endothelin-B (ET-B) receptors to resting vascular tone differs between genders, we administered the ET-B receptor antagonist BQ-788 into the forearm skin of 11 male and 11 female subjects by intradermal microdialysis. Skin blood flow was measured using laser-Doppler flowmetry at the microdialysis site. The probe was perfused with Ringer solution alone, followed by BQ-788 (150 nM) and finally sodium nitroprusside (28 mM) to effect maximal cutaneous vasodilation. Cutaneous vascular conductance (CVC) was calculated (laser-Doppler flowmetry/mean arterial pressure) and normalized to maximal levels (%max). In male subjects, baseline CVC was (mean ± SE) 19 ± 3%max and increased to 26 ± 5%max with BQ-788 (P < 0.05 vs. baseline). In female subjects, baseline CVC was 13 ± 1%max and decreased to 10 ± 1%max in response to BQ-788. CVC responses to BQ788 differed with gender (P < 0.05); thus the contribution of ET-B receptors to resting cutaneous vascular tone differs between men and women. In men, ET-B receptors mediate tonic vasoconstriction, whereas, in women, ET-B receptors mediate tonic vasodilation.

Original languageEnglish (US)
Pages (from-to)2407-2411
Number of pages5
JournalJournal of applied physiology
Volume91
Issue number5
DOIs
StatePublished - 2001

Keywords

  • Laser-Doppler flowmetry
  • Microdialysis
  • Skin blood flow

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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