Genetics of systemic lupus erythematosus: contributions of mouse models in the era of human genome-wide association studies.

Zhiwei Xu, Laurence Morel

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The past two years have brought great progress in the genetics of systemic lupus erythematosus (SLE) heralded by the publication of genome-wide association studies in humans and the identification of susceptibility genes in mouse models of spontaneous lupus. This influx of new information has revealed an ever-increasing interdependence between the mouse and human systems for unraveling the genetic basis of lupus susceptibility. SLE is a complex disease in which defects in several functional pathways have been identified. Genetic variants in a number of genes in these pathways have now been directly associated with lupus in both species. These discoveries have lead to a better understanding of the mechanisms of disease, and offer potential novel target for therapeutic intervention. As a large number of susceptibility genes are identified, lupus genetics will focus on mechanistic and molecular studies, in which mouse models will continue to serve a pre-eminent role.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalDiscovery medicine
Volume10
Issue number50
StatePublished - Jul 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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