Genetics of ocular NAD+-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse: Evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler

Roger S. Holmes; Raymond A. Popp; John L. VandeBerg

doi:10.1007/BF00561459

Genetics of ocular NAD⁺-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse: Evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler

Roger S. Holmes, Raymond A. Popp, John L. VandeBerg

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Electrophoretic and activity variation of the stomach and ocular isozyme of aldehyde dehydrogenase (designated AHD-4) was observed between C57BL/6J and SWR/J inbred strains of mice. The phenotypes were inherited in a normal mendelian fashion, with two alleles at a single locus (Ahd-4) showing codominant expression. The alleles assorted independently of those at Adh-3 [encoding the stomach and ocular isozyme of alcohol dehydrogenase (ADH-C₂)] on chromosome 3. Three chromosome 11 markers, hemoglobin α-chain (Hba), trembler (Tr), and rex (Re), were used in backcross analyses which established that Ahd-4 is closely linked to trembler. The distribution patterns for stomach and ocular AHD-4 phenotypes were examined among SWXL recombinant inbred mice, and those for stomach and ocular ADH-C₂ among BXD recombinant inbred strains. The data provided evidence for the genetic identity of stomach and ocular ADH-C₂ and of stomach and ocular AHD-4.

Original language	English (US)
Pages (from-to)	191-205
Number of pages	15
Journal	Biochemical Genetics
Volume	26
Issue number	3-4
DOIs	https://doi.org/10.1007/BF00561459
State	Published - Apr 1 1988

Keywords

alcohol dehydrogenase
aldehyde dehydrogenase
eye
mouse
stomach

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Biochemistry
Molecular Biology
Genetics

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10.1007/BF00561459

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Genetics of ocular NAD⁺-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse : Evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler. / Holmes, Roger S.; Popp, Raymond A.; VandeBerg, John L.

In: Biochemical Genetics, Vol. 26, No. 3-4, 01.04.1988, p. 191-205.

Research output: Contribution to journal › Article › peer-review

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abstract = "Electrophoretic and activity variation of the stomach and ocular isozyme of aldehyde dehydrogenase (designated AHD-4) was observed between C57BL/6J and SWR/J inbred strains of mice. The phenotypes were inherited in a normal mendelian fashion, with two alleles at a single locus (Ahd-4) showing codominant expression. The alleles assorted independently of those at Adh-3 [encoding the stomach and ocular isozyme of alcohol dehydrogenase (ADH-C2)] on chromosome 3. Three chromosome 11 markers, hemoglobin α-chain (Hba), trembler (Tr), and rex (Re), were used in backcross analyses which established that Ahd-4 is closely linked to trembler. The distribution patterns for stomach and ocular AHD-4 phenotypes were examined among SWXL recombinant inbred mice, and those for stomach and ocular ADH-C2 among BXD recombinant inbred strains. The data provided evidence for the genetic identity of stomach and ocular ADH-C2 and of stomach and ocular AHD-4.",

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