Genetics of ocular NAD+-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse: Evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler

Roger S. Holmes, Raymond A. Popp, John L. VandeBerg

    Research output: Contribution to journalArticle

    31 Scopus citations

    Abstract

    Electrophoretic and activity variation of the stomach and ocular isozyme of aldehyde dehydrogenase (designated AHD-4) was observed between C57BL/6J and SWR/J inbred strains of mice. The phenotypes were inherited in a normal mendelian fashion, with two alleles at a single locus (Ahd-4) showing codominant expression. The alleles assorted independently of those at Adh-3 [encoding the stomach and ocular isozyme of alcohol dehydrogenase (ADH-C2)] on chromosome 3. Three chromosome 11 markers, hemoglobin α-chain (Hba), trembler (Tr), and rex (Re), were used in backcross analyses which established that Ahd-4 is closely linked to trembler. The distribution patterns for stomach and ocular AHD-4 phenotypes were examined among SWXL recombinant inbred mice, and those for stomach and ocular ADH-C2 among BXD recombinant inbred strains. The data provided evidence for the genetic identity of stomach and ocular ADH-C2 and of stomach and ocular AHD-4.

    Original languageEnglish (US)
    Pages (from-to)191-205
    Number of pages15
    JournalBiochemical Genetics
    Volume26
    Issue number3-4
    DOIs
    StatePublished - Apr 1 1988

    Keywords

    • alcohol dehydrogenase
    • aldehyde dehydrogenase
    • eye
    • mouse
    • stomach

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Biochemistry
    • Molecular Biology
    • Genetics

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