Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: The Zuni Kidney Project

Sandra L. Laston, V. Saroja Voruganti, Karin Haack, Vallabh O. Shah, Arlene Bobelu, Jeanette Bobelu, Donica Ghahate, Antonia M. Harford, Susan S. Paine, Francesca Tentori, Shelley A. Cole, Jean W. MacCluer, Anthony G. Comuzzie, Philip G. Zager

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Original languageEnglish
Article number6
JournalFrontiers in Genetics
Volume5
Issue numberJAN
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Inborn Genetic Diseases
Kidney Diseases
Chronic Renal Insufficiency
Phenotype
Kidney
Single Nucleotide Polymorphism
Genes
Community-Based Participatory Research
Blood Pressure
Hyperuricemia
Uric Acid
Serum
Population Groups
Siblings
Creatinine
Triglycerides
Cholesterol
Hypertension
Population

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Genetics(clinical)

Cite this

Laston, S. L., Voruganti, V. S., Haack, K., Shah, V. O., Bobelu, A., Bobelu, J., ... Zager, P. G. (2015). Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: The Zuni Kidney Project. Frontiers in Genetics, 5(JAN), [6]. https://doi.org/10.3389/fgene.2015.00006

Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians : The Zuni Kidney Project. / Laston, Sandra L.; Voruganti, V. Saroja; Haack, Karin; Shah, Vallabh O.; Bobelu, Arlene; Bobelu, Jeanette; Ghahate, Donica; Harford, Antonia M.; Paine, Susan S.; Tentori, Francesca; Cole, Shelley A.; MacCluer, Jean W.; Comuzzie, Anthony G.; Zager, Philip G.

In: Frontiers in Genetics, Vol. 5, No. JAN, 6, 2015.

Research output: Contribution to journalArticle

Laston, SL, Voruganti, VS, Haack, K, Shah, VO, Bobelu, A, Bobelu, J, Ghahate, D, Harford, AM, Paine, SS, Tentori, F, Cole, SA, MacCluer, JW, Comuzzie, AG & Zager, PG 2015, 'Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: The Zuni Kidney Project', Frontiers in Genetics, vol. 5, no. JAN, 6. https://doi.org/10.3389/fgene.2015.00006
Laston, Sandra L. ; Voruganti, V. Saroja ; Haack, Karin ; Shah, Vallabh O. ; Bobelu, Arlene ; Bobelu, Jeanette ; Ghahate, Donica ; Harford, Antonia M. ; Paine, Susan S. ; Tentori, Francesca ; Cole, Shelley A. ; MacCluer, Jean W. ; Comuzzie, Anthony G. ; Zager, Philip G. / Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians : The Zuni Kidney Project. In: Frontiers in Genetics. 2015 ; Vol. 5, No. JAN.
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title = "Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: The Zuni Kidney Project",
abstract = "The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24{\%}, 30{\%}, 17{\%} and 34{\%}, respectively. We found a significant (p < 1.58 × 10-7) association for a SNP in a novel gene for serum creatinine (PTPLAD2). We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). We found novel suggestive associations (p < 1.58 × 10-6) for SNPs in genes with systolic (OLFML2B), and diastolic blood pressure (NFIA). We identified a series of genes associated with CKD and related cardiometabolic phenotypes among Zuni Indians, a population with a high prevalence of kidney disease. Illuminating genetic variations that modulate the risk for these disorders may ultimately provide a basis for novel preventive strategies and therapeutic interventions.",
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T1 - Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians

T2 - The Zuni Kidney Project

AU - Laston, Sandra L.

AU - Voruganti, V. Saroja

AU - Haack, Karin

AU - Shah, Vallabh O.

AU - Bobelu, Arlene

AU - Bobelu, Jeanette

AU - Ghahate, Donica

AU - Harford, Antonia M.

AU - Paine, Susan S.

AU - Tentori, Francesca

AU - Cole, Shelley A.

AU - MacCluer, Jean W.

AU - Comuzzie, Anthony G.

AU - Zager, Philip G.

PY - 2015

Y1 - 2015

N2 - The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24%, 30%, 17% and 34%, respectively. We found a significant (p < 1.58 × 10-7) association for a SNP in a novel gene for serum creatinine (PTPLAD2). We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). We found novel suggestive associations (p < 1.58 × 10-6) for SNPs in genes with systolic (OLFML2B), and diastolic blood pressure (NFIA). We identified a series of genes associated with CKD and related cardiometabolic phenotypes among Zuni Indians, a population with a high prevalence of kidney disease. Illuminating genetic variations that modulate the risk for these disorders may ultimately provide a basis for novel preventive strategies and therapeutic interventions.

AB - The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24%, 30%, 17% and 34%, respectively. We found a significant (p < 1.58 × 10-7) association for a SNP in a novel gene for serum creatinine (PTPLAD2). We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). We found novel suggestive associations (p < 1.58 × 10-6) for SNPs in genes with systolic (OLFML2B), and diastolic blood pressure (NFIA). We identified a series of genes associated with CKD and related cardiometabolic phenotypes among Zuni Indians, a population with a high prevalence of kidney disease. Illuminating genetic variations that modulate the risk for these disorders may ultimately provide a basis for novel preventive strategies and therapeutic interventions.

KW - Association

KW - Kidney function

KW - Serum uric acid

KW - Single nucleotide polymorphisms

KW - Triglycerides

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