Genetics of Human Host Susceptibility to Ascariasis

Sarah Williams-Blangero, Mona H. Fenstad, Satish Kumar, John Blangero

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Scopus citations

    Abstract

    Ascaris infections remain major global public health problems despite the wide availability of cheap, effective anthelminthic drugs. An improved understanding of host susceptibility to Ascaris infection may suggest new approaches for targeting available drugs more effectively, or may suggest novel targets for drug development efforts. This chapter explores our current understanding of the underlying genetic architecture of susceptibility to Ascaris infection. The past and potential future uses of different types of genetic approaches, from quantitative genetic studies of heritability, to gene localization, to sequencing of functional variants, are explored. The field of human complex disease genetics is moving rapidly as a result of both technological and theoretical advances. State-of-the-art genetic techniques promise to yield new insights which will dramatically improve our understanding of the determinants of differential host susceptibility to Ascaris infection. © 2013

    Original languageEnglish (US)
    Title of host publicationAscaris
    Subtitle of host publicationThe Neglected Parasite
    PublisherElsevier Inc.
    Pages315-340
    Number of pages26
    ISBN (Print)9780123969781
    DOIs
    StatePublished - Aug 27 2013

    Keywords

    • Ascaris infection
    • Heritability
    • Host genetic factors
    • Pedigree analysis
    • Quantitative trait locus (QTL)

    ASJC Scopus subject areas

    • Immunology and Microbiology(all)

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