Genetics of Human Host Susceptibility to Ascariasis

Sarah Williams-Blangero; Mona H. Fenstad; Satish Kumar; John Blangero

doi:10.1016/B978-0-12-396978-1.00012-4

Genetics of Human Host Susceptibility to Ascariasis

Sarah Williams-Blangero, Mona H. Fenstad, Satish Kumar, John Blangero

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Ascaris infections remain major global public health problems despite the wide availability of cheap, effective anthelminthic drugs. An improved understanding of host susceptibility to Ascaris infection may suggest new approaches for targeting available drugs more effectively, or may suggest novel targets for drug development efforts. This chapter explores our current understanding of the underlying genetic architecture of susceptibility to Ascaris infection. The past and potential future uses of different types of genetic approaches, from quantitative genetic studies of heritability, to gene localization, to sequencing of functional variants, are explored. The field of human complex disease genetics is moving rapidly as a result of both technological and theoretical advances. State-of-the-art genetic techniques promise to yield new insights which will dramatically improve our understanding of the determinants of differential host susceptibility to Ascaris infection. © 2013

Original language	English (US)
Title of host publication	Ascaris
Subtitle of host publication	The Neglected Parasite
Publisher	Elsevier Inc.
Pages	315-340
Number of pages	26
ISBN (Print)	9780123969781
DOIs	https://doi.org/10.1016/B978-0-12-396978-1.00012-4
State	Published - 2013

Keywords

Ascaris infection
Heritability
Host genetic factors
Pedigree analysis
Quantitative trait locus (QTL)

ASJC Scopus subject areas

Immunology and Microbiology(all)

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10.1016/B978-0-12-396978-1.00012-4

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title = "Genetics of Human Host Susceptibility to Ascariasis",

abstract = "Ascaris infections remain major global public health problems despite the wide availability of cheap, effective anthelminthic drugs. An improved understanding of host susceptibility to Ascaris infection may suggest new approaches for targeting available drugs more effectively, or may suggest novel targets for drug development efforts. This chapter explores our current understanding of the underlying genetic architecture of susceptibility to Ascaris infection. The past and potential future uses of different types of genetic approaches, from quantitative genetic studies of heritability, to gene localization, to sequencing of functional variants, are explored. The field of human complex disease genetics is moving rapidly as a result of both technological and theoretical advances. State-of-the-art genetic techniques promise to yield new insights which will dramatically improve our understanding of the determinants of differential host susceptibility to Ascaris infection. {\textcopyright} 2013",

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author = "Sarah Williams-Blangero and Fenstad, {Mona H.} and Satish Kumar and John Blangero",

note = "Funding Information: We gratefully acknowledge the Jirel people for their participation in our studies of helminthic infection. The new data reported in this chapter were generated under protocols approved by the University of Texas Health Science Center at San Antonio Institutional Review Board and the Nepal Health Research Council. This work was supported by National Institutes of Health grants AI44406, AI37091, HL045522, and MH59490. The lymphocyte expression profiling was supported by a generous donation from the Azar/Shepperd families with additional funds from ChemGenex Pharmaceuticals, Ltd. The work presented in this chapter was conducted in facilities that were constructed with partial support from NIH grants C06 RR017515 and C06 RR013556. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

year = "2013",

doi = "10.1016/B978-0-12-396978-1.00012-4",

language = "English (US)",

isbn = "9780123969781",

pages = "315--340",

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AU - Williams-Blangero, Sarah

AU - Fenstad, Mona H.

AU - Kumar, Satish

AU - Blangero, John

N1 - Funding Information: We gratefully acknowledge the Jirel people for their participation in our studies of helminthic infection. The new data reported in this chapter were generated under protocols approved by the University of Texas Health Science Center at San Antonio Institutional Review Board and the Nepal Health Research Council. This work was supported by National Institutes of Health grants AI44406, AI37091, HL045522, and MH59490. The lymphocyte expression profiling was supported by a generous donation from the Azar/Shepperd families with additional funds from ChemGenex Pharmaceuticals, Ltd. The work presented in this chapter was conducted in facilities that were constructed with partial support from NIH grants C06 RR017515 and C06 RR013556. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.

PY - 2013

Y1 - 2013

N2 - Ascaris infections remain major global public health problems despite the wide availability of cheap, effective anthelminthic drugs. An improved understanding of host susceptibility to Ascaris infection may suggest new approaches for targeting available drugs more effectively, or may suggest novel targets for drug development efforts. This chapter explores our current understanding of the underlying genetic architecture of susceptibility to Ascaris infection. The past and potential future uses of different types of genetic approaches, from quantitative genetic studies of heritability, to gene localization, to sequencing of functional variants, are explored. The field of human complex disease genetics is moving rapidly as a result of both technological and theoretical advances. State-of-the-art genetic techniques promise to yield new insights which will dramatically improve our understanding of the determinants of differential host susceptibility to Ascaris infection. © 2013

AB - Ascaris infections remain major global public health problems despite the wide availability of cheap, effective anthelminthic drugs. An improved understanding of host susceptibility to Ascaris infection may suggest new approaches for targeting available drugs more effectively, or may suggest novel targets for drug development efforts. This chapter explores our current understanding of the underlying genetic architecture of susceptibility to Ascaris infection. The past and potential future uses of different types of genetic approaches, from quantitative genetic studies of heritability, to gene localization, to sequencing of functional variants, are explored. The field of human complex disease genetics is moving rapidly as a result of both technological and theoretical advances. State-of-the-art genetic techniques promise to yield new insights which will dramatically improve our understanding of the determinants of differential host susceptibility to Ascaris infection. © 2013

KW - Ascaris infection

KW - Heritability

KW - Host genetic factors

KW - Pedigree analysis

KW - Quantitative trait locus (QTL)

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ER -

Genetics of Human Host Susceptibility to Ascariasis

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Keywords

ASJC Scopus subject areas

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