Genetics and caging type affect birth weight in captive pigtailed macaques (Macaca nemestrina)

James C. Ha, Renee Robinette Ha, Laura Almasy, Bennett Dyke

    Research output: Contribution to journalArticlepeer-review

    18 Scopus citations

    Abstract

    The heritability of birth weight was estimated in 3,562 captive pigtailed macaques using 30 years of breeding and pedigree records. Based on a pedigree of over 12,000 animals, quantitative genetic analyses were performed using statistical variance decomposition methods. The model included additive genetic effects, cytoplasmic genetic effects, birth environment, shared maternal environment, and unmeasured environmental effects. The results demonstrated a strong (h2= 0.51) heritable component of birth weight overall, and included significant additive genetic heritability (h2 = 0.23), and cytoplasmic heritability (h2 = 0.09). In addition, a significant effect of birth location and cage type was identified, explaining an additional 6% of birth weight variance. The use of a nonhuman primate model for studying the effects of genes on birth weight eliminated many of the problems associated with confounding variables in human studies, and allowed for the quantification of a heritable component of birth weight.

    Original languageEnglish (US)
    Pages (from-to)207-213
    Number of pages7
    JournalAmerican Journal of Primatology
    Volume56
    Issue number4
    DOIs
    StatePublished - 2002

    Keywords

    • Mitochondrial inheritance
    • Quantitative genetics
    • Variance decomposition

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Animal Science and Zoology

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