@article{65d68327198647b9a9509b0ddbf1fa47,
title = "Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease",
abstract = "Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods: Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger. Results: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P >.7). Discussion: Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD.",
keywords = "Cholesteryl ester transfer protein, Genetics, HDL-C, Instrumental variables, Single nucleotide polymorphisms",
author = "\{ARUK Consortium\} and \{GERAD/PERADES, CHARGE, ADGC, EADI\} and \{International Genomics of Alzheimer's Project (IGAP)\} and \{ARUK Consortium\} and \{GERAD/PERADES, CHARGE, ADGC, EADI\} and Peloso, \{Gina M.\} and \{van der Lee\}, \{Sven J.\} and R. Sims and \{van der Lee\}, \{S. J.\} and Naj, \{A. C.\} and C. Bellenguez and N. Badarinarayan and J. Jakobsdottir and Kunkle, \{B. W.\} and A. Boland and R. Raybould and Bis, \{J. C.\} and Martin, \{E. R.\} and B. Grenier-Boley and S. Heilmann-Heimbach and V. Chouraki and Kuzma, \{A. B.\} and K. Sleegers and M. Vronskaya and A. Ruiz and Graham, \{R. R.\} and R. Olaso and P. Hoffmann and Grove, \{M. L.\} and Vardarajan, \{B. N.\} and M. Hiltunen and N{\"o}then, \{M. M.\} and White, \{C. C.\} and Hamilton-Nelson, \{K. L.\} and J. Epelbaum and W. Maier and Choi, \{S. H.\} and Beecham, \{G. W.\} and C. Dulary and S. Herms and Smith, \{A. V.\} and Funk, \{C. C.\} and Derbois and Forstner, \{A. J.\} and S. Ahmad and H. Li and D. Bacq and D. Harold and Satizabal, \{C. L.\} and O. Valladares and A. Squassina and X. Jian and Himali, \{J. J.\} and Royall, \{D. R.\} and S. Seshadri",
note = "Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.dadm.2018.08.008",
language = "English (US)",
volume = "10",
pages = "595--598",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "John Wiley and Sons Inc.",
}