Genetically Appropriate Expression of HLA and DR (IA) Alloantigens on Human Melanoma Cell Lines

Marilyn S. Pollack, Philip O. Livingston, Jorgen Fogh, Thomas E. Carey, Herbert F. Oettgen, Bo Dupont

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Studies of the expression of HLA and DR alloantigens on cultured human melanoma cells in comparison with those expressed on peripheral lymphocytes and B‐cells derived from the same patients have shown that the HLA‐A B, and C locus antigens expressed on the cultured tumor cells were consistent with those expected from the typing of periperal blood lymphocytes. One melanoma cell line failed to express all the HLA antigens expected from donor typing. All five of the lines tested also expressed DR antigens and in three instances these could be demonstrated to have genetically consistent allotypes. However, in preliminary studies, stimulation of allogeneic lymphocytes by the DR positive melanoma cells could not be demonstrated.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalTissue Antigens
Volume15
Issue number3
DOIs
StatePublished - Mar 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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