Genetic variation and immunochemical properties of L-malate: NAD+ oxidoreductase isozymes in the bandicoot, isoodon macrourus

R. S. Holmes, J. L. Vande Berg, G. Gordon

    Research output: Contribution to journalArticlepeer-review


    A genetic polymorphism for the soluble isozyme (MDH-A2) of malate dehydrogenase (L-malate: NAD+ oxidoreductase; EC was found in a Townsville-Inkerman population of short-nosed bandicoots, 1. macrourus. The enzyme seems to be inherited in a normal autosomal codominant manner. The gene frequencies for the MDH-A and MDH-A′ alleles were 0·82 and 0·18 respectively. The genotypic frequencies indicated that the population was in Hardy-Weinberg equilibrium. None of 22 pouch young from seven litters expressed a phenotype inconsistent with its mother’s genotype, assuming autosomal co dominance. Other populations of I. macrourus and of the long-nosed bandicoot (Perameles nasuta) exhibited only the MDH-A allele. Homologous relationships of bandicoot MDH-A2 and MDH-B2 isozymes to those of other vertebrates were established by immunochemical studies.

    Original languageEnglish (US)
    Pages (from-to)677-682
    Number of pages6
    JournalAustralian Journal of Biological Sciences
    Issue number6
    StatePublished - 1974

    ASJC Scopus subject areas

    • Biotechnology
    • Reproductive Medicine
    • Animal Science and Zoology
    • Molecular Biology
    • Materials Science(all)
    • Genetics
    • Endocrinology
    • Developmental Biology


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