Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate

Anna J. Jasinska, Ivette Zelaya, Susan K. Service, Christine B. Peterson, Rita M. Cantor, Oi Wa Choi, Joseph DeYoung, Eleazar Eskin, Lynn A. Fairbanks, Scott Fears, Allison E. Furterer, Yu S. Huang, Vasily Ramensky, Christopher A. Schmitt, Hannes Svardal, Matthew J. Jorgensen, Jay R. Kaplan, Diego Villar, Bronwen L. Aken, Paul FlicekRishi Nag, Emily S. Wong, John Blangero, Thomas D. Dyer, Marina Bogomolov, Yoav Benjamini, George M. Weinstock, Ken Dewar, Chiara Sabatti, Richard K. Wilson, David J. Jentsch, Wesley Warren, Giovanni Coppola, Roger P. Woods, Nelson B. Freimer

    Research output: Contribution to journalArticle

    15 Scopus citations

    Abstract

    By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex-A nd age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.

    Original languageEnglish (US)
    Pages (from-to)1714-1721
    Number of pages8
    JournalNature Genetics
    Volume49
    Issue number12
    DOIs
    StatePublished - Dec 1 2017

    ASJC Scopus subject areas

    • Genetics

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    Jasinska, A. J., Zelaya, I., Service, S. K., Peterson, C. B., Cantor, R. M., Choi, O. W., DeYoung, J., Eskin, E., Fairbanks, L. A., Fears, S., Furterer, A. E., Huang, Y. S., Ramensky, V., Schmitt, C. A., Svardal, H., Jorgensen, M. J., Kaplan, J. R., Villar, D., Aken, B. L., ... Freimer, N. B. (2017). Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nature Genetics, 49(12), 1714-1721. https://doi.org/10.1038/ng.3959