Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Georg B. Ehret, Patricia B. Munroe, Kenneth M. Rice, Murielle Bochud, Andrew D. Johnson, Daniel I. Chasman, Albert V. Smith, Martin D. Tobin, Germaine C. Verwoert, Shih Jen Hwang, Vasyl Pihur, Peter Vollenweider, Paul F. O'Reilly, Najaf Amin, Jennifer L. Bragg-Gresham, Alexander Teumer, Nicole L. Glazer, Lenore Launer, Jing Hua Zhao, Yurii Aulchenko & 326 others Simon Heath, Siim Sober, Afshin Parsa, Jian'an Luan, Pankaj Arora, Abbas Dehghan, Feng Zhang, Gavin Lucas, Andrew A. Hicks, Anne U. Jackson, John F. Peden, Toshiko Tanaka, Sarah H. Wild, Igor Rudan, Wilmar Igl, Yuri Milaneschi, Alex N. Parker, Cristiano Fava, John C. Chambers, Ervin R. Fox, Meena Kumari, Min Jin Go, Pim van der Harst, Wen Hong Linda Kao, Marketa Sjögren, D. G. Vinay, Myriam Alexander, Yasuharu Tabara, Sue Shaw-Hawkins, Peter H. Whincup, Yongmei Liu, Gang Shi, Johanna Kuusisto, Bamidele Tayo, Mark Seielstad, Xueling Sim, Khanh Dung Hoang Nguyen, Terho Lehtimäki, Giuseppe Matullo, Ying Wu, Tom R. Gaunt, N. Charlotte Onland-Moret, Matthew N. Cooper, Carl G.P. Platou, Elin Org, Rebecca Hardy, Santosh Dahgam, Jutta Palmen, Veronique Vitart, Peter S. Braund, Tatiana Kuznetsova, Cuno S.P.M. Uiterwaal, Adebowale Adeyemo, Walter Palmas, Harry Campbell, Barbara Ludwig, Maciej Tomaszewski, Ioanna Tzoulaki, Nicholette D. Palmer, Thor Aspelund, Melissa Garcia, Yen Pei C. Chang, Jeffrey R. O'Connell, Nanette I. Steinle, Diederick E. Grobbee, Dan E. Arking, Sharon L. Kardia, Alanna C. Morrison, Dena Hernandez, Samer Najjar, Wendy L. McArdle, David Hadley, Morris J. Brown, John M. Connell, Aroon D. Hingorani, Ian N.M. Day, Debbie A. Lawlor, John P. Beilby, Robert W. Lawrence, Robert Clarke, Jemma C. Hopewell, Halit Ongen, Albert W. Dreisbach, Yali Li, J. Hunter Young, Joshua C. Bis, Mika Kähönen, Jorma Viikari, Linda S. Adair, Nanette R. Lee, Ming Huei Chen, Matthias Olden, Cristian Pattaro, Judith A.Hoffman Bolton, Anna Köttgen, Sven Bergmann, Vincent Mooser, Nish Chaturvedi, Timothy M. Frayling, Muhammad Islam, Tazeen H. Jafar, Jeanette Erdmann, Smita R. Kulkarni, Stefan R. Bornstein, Jürgen Grässler, Leif Groop, Benjamin F. Voight, Johannes Kettunen, Philip Howard, Andrew Taylor, Simonetta Guarrera, Fulvio Ricceri, Valur Emilsson, Andrew Plump, Inês Barroso, Kay Tee Khaw, Alan B. Weder, Steven C. Hunt, Yan V. Sun, Richard N. Bergman, Francis S. Collins, Lori L. Bonnycastle, Laura J. Scott, Heather M. Stringham, Leena Peltonen, Markus Perola, Erkki Vartiainen, Stefan Martin Brand, Jan A. Staessen, Thomas J. Wang, Paul R. Burton, Maria Soler Artigas, Yanbin Dong, Harold Snieder, Xiaoling Wang, Haidong Zhu, Kurt K. Lohman, Megan E. Rudock, Susan R. Heckbert, Nicholas L. Smith, Kerri L. Wiggins, Ayo Doumatey, Daniel Shriner, Gudrun Veldre, Margus Viigimaa, Sanjay Kinra, Dorairaj Prabhakaran, Vikal Tripathy, Carl D. Langefeld, Annika Rosengren, Dag S. Thelle, Anna Maria Corsi, Andrew Singleton, Terrence Forrester, Gina Hilton, Colin A. McKenzie, Tunde Salako, Naoharu Iwai, Yoshikuni Kita, Toshio Ogihara, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Satoshi Umemura, Susana Eyheramendy, Thomas Meitinger, H. Erich Wichmann, Yoon Shin Cho, Hyung Lae Kim, Jong Young Lee, James Scott, Joban S. Sehmi, Weihua Zhang, Bo Hedblad, Peter Nilsson, George Davey Smith, Andrew Wong, Narisu Narisu, Alena Stančáková, Leslie J. Raffel, Jie Yao, Sekar Kathiresan, Christopher J. O'Donnell, Stephen M. Schwartz, M. Arfan Ikram, W. T. Longstreth, Thomas H. Mosley, Sudha Seshadri, Nick R.G. Shrine, Louise V. Wain, Mario A. Morken, Amy J. Swift, Jaana Laitinen, Inga Prokopenko, Paavo Zitting, Jackie A. Cooper, Steve E. Humphries, John Danesh, Asif Rasheed, Anuj Goel, Anders Hamsten, Hugh Watkins, Stephan J.L. Bakker, Wiek H. van Gilst, Charles S. Janipalli, K. Radha Mani, Chittaranjan S. Yajnik, Albert Hofman, Francesco U.S. Mattace-Raso, Ben A. Oostra, Ayse Demirkan, Aaron Isaacs, Fernando Rivadeneira, Edward G. Lakatta, Marco Orru, Angelo Scuteri, Mika Ala-Korpela, Antti J. Kangas, Leo Pekka Lyytikäinen, Pasi Soininen, Taru Tukiainen, Peter Würtz, Rick Twee-HeeOng, Marcus Dörr, Heyo K. Kroemer, Uwe Völker, Henry Völzke, Pilar Galan, Serge Hercberg, Mark Lathrop, Diana Zelenika, Panos Deloukas, Massimo Mangino, Tim D. Spector, Guangju Zhai, James F. Meschia, Michael A. Nalls, Pankaj Sharma, Janos Terzic, M. V. Kranthi Kumar, Matthew Denniff, Ewa Zukowska-Szczechowska, Lynne E. Wagenknecht, F. Gerald R. Fowkes, Fadi J. Charchar, Peter E.H. Schwarz, Caroline Hayward, Xiuqing Guo, Charles Rotimi, Michiel L. Bots, Eva Brand, Nilesh J. Samani, Ozren Polasek, Philippa J. Talmud, Fredrik Nyberg, Diana Kuh, Maris Laan, Kristian Hveem, Lyle J. Palmer, Yvonne T. van der Schouw, Juan P. Casas, Karen L. Mohlke, Paolo Vineis, Olli Raitakari, Santhi K. Ganesh, Tien Y. Wong, E. Shyong Tai, Richard S. Cooper, Markku Laakso, Dabeeru C. Rao, Tamara B. Harris, Richard W. Morris, Anna F. Dominiczak, Mika Kivimaki, Michael G. Marmot, Tetsuro Miki, Danish Saleheen, Giriraj R. Chandak, Josef Coresh, Gerjan Navis, Veikko Salomaa, Bok Ghee Han, Xiaofeng Zhu, Jaspal S. Kooner, Olle Melander, Paul M. Ridker, Stefania Bandinelli, Ulf B. Gyllensten, Alan F. Wright, James F. Wilson, Luigi Ferrucci, Martin Farrall, Jaakko Tuomilehto, Peter P. Pramstaller, Roberto Elosua, Nicole Soranzo, Eric J.G. Sijbrands, David Altshuler, Ruth J.F. Loos, Alan R. Shuldiner, Christian Gieger, Pierre Meneton, Andre G. Uitterlinden, Nicholas J. Wareham, Vilmundur Gudnason, Jerome I. Rotter, Rainer Rettig, Manuela Uda, David P. Strachan, Jacqueline C.M. Witteman, Anna Liisa Hartikainen, Jacques S. Beckmann, Eric Boerwinkle, Ramachandran S. Vasan, Michael Boehnke, Martin G. Larson, Marjo Riitta Järvelin, Bruce M. Psaty, Gonçalo R. Abecasis, Aravinda Chakravarti, Paul Elliott, Cornelia M. van Duijn, Christopher Newton-Cheh, Daniel Levy, Mark J. Caulfield, Toby Johnson

Research output: Contribution to journalArticle

1237 Citations (Scopus)

Abstract

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140mmg Hg systolic blood pressure ≥90mmg Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3 GUCY1B3, NPR3 C5orf23, ADM, FURIN FES, GOSR2, GNAS EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalNature
Volume478
Issue number7367
DOIs
StatePublished - Oct 6 2011
Externally publishedYes

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Hematologic Diseases
Cardiovascular Diseases
Blood Pressure
Blood Physiological Phenomena
Furin
Hypertension
Genome-Wide Association Study
Kidney Diseases
Coronary Artery Disease
Stroke
Genome

ASJC Scopus subject areas

  • General

Cite this

Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., ... Johnson, T. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103-109. https://doi.org/10.1038/nature10405

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. / Ehret, Georg B.; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C.; Hwang, Shih Jen; Pihur, Vasyl; Vollenweider, Peter; O'Reilly, Paul F.; Amin, Najaf; Bragg-Gresham, Jennifer L.; Teumer, Alexander; Glazer, Nicole L.; Launer, Lenore; Zhao, Jing Hua; Aulchenko, Yurii; Heath, Simon; Sober, Siim; Parsa, Afshin; Luan, Jian'an; Arora, Pankaj; Dehghan, Abbas; Zhang, Feng; Lucas, Gavin; Hicks, Andrew A.; Jackson, Anne U.; Peden, John F.; Tanaka, Toshiko; Wild, Sarah H.; Rudan, Igor; Igl, Wilmar; Milaneschi, Yuri; Parker, Alex N.; Fava, Cristiano; Chambers, John C.; Fox, Ervin R.; Kumari, Meena; Go, Min Jin; van der Harst, Pim; Kao, Wen Hong Linda; Sjögren, Marketa; Vinay, D. G.; Alexander, Myriam; Tabara, Yasuharu; Shaw-Hawkins, Sue; Whincup, Peter H.; Liu, Yongmei; Shi, Gang; Kuusisto, Johanna; Tayo, Bamidele; Seielstad, Mark; Sim, Xueling; Hoang Nguyen, Khanh Dung; Lehtimäki, Terho; Matullo, Giuseppe; Wu, Ying; Gaunt, Tom R.; Charlotte Onland-Moret, N.; Cooper, Matthew N.; Platou, Carl G.P.; Org, Elin; Hardy, Rebecca; Dahgam, Santosh; Palmen, Jutta; Vitart, Veronique; Braund, Peter S.; Kuznetsova, Tatiana; Uiterwaal, Cuno S.P.M.; Adeyemo, Adebowale; Palmas, Walter; Campbell, Harry; Ludwig, Barbara; Tomaszewski, Maciej; Tzoulaki, Ioanna; Palmer, Nicholette D.; Aspelund, Thor; Garcia, Melissa; Chang, Yen Pei C.; O'Connell, Jeffrey R.; Steinle, Nanette I.; Grobbee, Diederick E.; Arking, Dan E.; Kardia, Sharon L.; Morrison, Alanna C.; Hernandez, Dena; Najjar, Samer; McArdle, Wendy L.; Hadley, David; Brown, Morris J.; Connell, John M.; Hingorani, Aroon D.; Day, Ian N.M.; Lawlor, Debbie A.; Beilby, John P.; Lawrence, Robert W.; Clarke, Robert; Hopewell, Jemma C.; Ongen, Halit; Dreisbach, Albert W.; Li, Yali; Hunter Young, J.; Bis, Joshua C.; Kähönen, Mika; Viikari, Jorma; Adair, Linda S.; Lee, Nanette R.; Chen, Ming Huei; Olden, Matthias; Pattaro, Cristian; Bolton, Judith A.Hoffman; Köttgen, Anna; Bergmann, Sven; Mooser, Vincent; Chaturvedi, Nish; Frayling, Timothy M.; Islam, Muhammad; Jafar, Tazeen H.; Erdmann, Jeanette; Kulkarni, Smita R.; Bornstein, Stefan R.; Grässler, Jürgen; Groop, Leif; Voight, Benjamin F.; Kettunen, Johannes; Howard, Philip; Taylor, Andrew; Guarrera, Simonetta; Ricceri, Fulvio; Emilsson, Valur; Plump, Andrew; Barroso, Inês; Khaw, Kay Tee; Weder, Alan B.; Hunt, Steven C.; Sun, Yan V.; Bergman, Richard N.; Collins, Francis S.; Bonnycastle, Lori L.; Scott, Laura J.; Stringham, Heather M.; Peltonen, Leena; Perola, Markus; Vartiainen, Erkki; Brand, Stefan Martin; Staessen, Jan A.; Wang, Thomas J.; Burton, Paul R.; Artigas, Maria Soler; Dong, Yanbin; Snieder, Harold; Wang, Xiaoling; Zhu, Haidong; Lohman, Kurt K.; Rudock, Megan E.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Doumatey, Ayo; Shriner, Daniel; Veldre, Gudrun; Viigimaa, Margus; Kinra, Sanjay; Prabhakaran, Dorairaj; Tripathy, Vikal; Langefeld, Carl D.; Rosengren, Annika; Thelle, Dag S.; Corsi, Anna Maria; Singleton, Andrew; Forrester, Terrence; Hilton, Gina; McKenzie, Colin A.; Salako, Tunde; Iwai, Naoharu; Kita, Yoshikuni; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Umemura, Satoshi; Eyheramendy, Susana; Meitinger, Thomas; Wichmann, H. Erich; Cho, Yoon Shin; Kim, Hyung Lae; Lee, Jong Young; Scott, James; Sehmi, Joban S.; Zhang, Weihua; Hedblad, Bo; Nilsson, Peter; Smith, George Davey; Wong, Andrew; Narisu, Narisu; Stančáková, Alena; Raffel, Leslie J.; Yao, Jie; Kathiresan, Sekar; O'Donnell, Christopher J.; Schwartz, Stephen M.; Arfan Ikram, M.; Longstreth, W. T.; Mosley, Thomas H.; Seshadri, Sudha; Shrine, Nick R.G.; Wain, Louise V.; Morken, Mario A.; Swift, Amy J.; Laitinen, Jaana; Prokopenko, Inga; Zitting, Paavo; Cooper, Jackie A.; Humphries, Steve E.; Danesh, John; Rasheed, Asif; Goel, Anuj; Hamsten, Anders; Watkins, Hugh; Bakker, Stephan J.L.; van Gilst, Wiek H.; Janipalli, Charles S.; Radha Mani, K.; Yajnik, Chittaranjan S.; Hofman, Albert; Mattace-Raso, Francesco U.S.; Oostra, Ben A.; Demirkan, Ayse; Isaacs, Aaron; Rivadeneira, Fernando; Lakatta, Edward G.; Orru, Marco; Scuteri, Angelo; Ala-Korpela, Mika; Kangas, Antti J.; Lyytikäinen, Leo Pekka; Soininen, Pasi; Tukiainen, Taru; Würtz, Peter; Twee-HeeOng, Rick; Dörr, Marcus; Kroemer, Heyo K.; Völker, Uwe; Völzke, Henry; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Zelenika, Diana; Deloukas, Panos; Mangino, Massimo; Spector, Tim D.; Zhai, Guangju; Meschia, James F.; Nalls, Michael A.; Sharma, Pankaj; Terzic, Janos; Kranthi Kumar, M. V.; Denniff, Matthew; Zukowska-Szczechowska, Ewa; Wagenknecht, Lynne E.; Fowkes, F. Gerald R.; Charchar, Fadi J.; Schwarz, Peter E.H.; Hayward, Caroline; Guo, Xiuqing; Rotimi, Charles; Bots, Michiel L.; Brand, Eva; Samani, Nilesh J.; Polasek, Ozren; Talmud, Philippa J.; Nyberg, Fredrik; Kuh, Diana; Laan, Maris; Hveem, Kristian; Palmer, Lyle J.; van der Schouw, Yvonne T.; Casas, Juan P.; Mohlke, Karen L.; Vineis, Paolo; Raitakari, Olli; Ganesh, Santhi K.; Wong, Tien Y.; Shyong Tai, E.; Cooper, Richard S.; Laakso, Markku; Rao, Dabeeru C.; Harris, Tamara B.; Morris, Richard W.; Dominiczak, Anna F.; Kivimaki, Mika; Marmot, Michael G.; Miki, Tetsuro; Saleheen, Danish; Chandak, Giriraj R.; Coresh, Josef; Navis, Gerjan; Salomaa, Veikko; Han, Bok Ghee; Zhu, Xiaofeng; Kooner, Jaspal S.; Melander, Olle; Ridker, Paul M.; Bandinelli, Stefania; Gyllensten, Ulf B.; Wright, Alan F.; Wilson, James F.; Ferrucci, Luigi; Farrall, Martin; Tuomilehto, Jaakko; Pramstaller, Peter P.; Elosua, Roberto; Soranzo, Nicole; Sijbrands, Eric J.G.; Altshuler, David; Loos, Ruth J.F.; Shuldiner, Alan R.; Gieger, Christian; Meneton, Pierre; Uitterlinden, Andre G.; Wareham, Nicholas J.; Gudnason, Vilmundur; Rotter, Jerome I.; Rettig, Rainer; Uda, Manuela; Strachan, David P.; Witteman, Jacqueline C.M.; Hartikainen, Anna Liisa; Beckmann, Jacques S.; Boerwinkle, Eric; Vasan, Ramachandran S.; Boehnke, Michael; Larson, Martin G.; Järvelin, Marjo Riitta; Psaty, Bruce M.; Abecasis, Gonçalo R.; Chakravarti, Aravinda; Elliott, Paul; van Duijn, Cornelia M.; Newton-Cheh, Christopher; Levy, Daniel; Caulfield, Mark J.; Johnson, Toby.

In: Nature, Vol. 478, No. 7367, 06.10.2011, p. 103-109.

Research output: Contribution to journalArticle

Ehret, GB, Munroe, PB, Rice, KM, Bochud, M, Johnson, AD, Chasman, DI, Smith, AV, Tobin, MD, Verwoert, GC, Hwang, SJ, Pihur, V, Vollenweider, P, O'Reilly, PF, Amin, N, Bragg-Gresham, JL, Teumer, A, Glazer, NL, Launer, L, Zhao, JH, Aulchenko, Y, Heath, S, Sober, S, Parsa, A, Luan, J, Arora, P, Dehghan, A, Zhang, F, Lucas, G, Hicks, AA, Jackson, AU, Peden, JF, Tanaka, T, Wild, SH, Rudan, I, Igl, W, Milaneschi, Y, Parker, AN, Fava, C, Chambers, JC, Fox, ER, Kumari, M, Go, MJ, van der Harst, P, Kao, WHL, Sjögren, M, Vinay, DG, Alexander, M, Tabara, Y, Shaw-Hawkins, S, Whincup, PH, Liu, Y, Shi, G, Kuusisto, J, Tayo, B, Seielstad, M, Sim, X, Hoang Nguyen, KD, Lehtimäki, T, Matullo, G, Wu, Y, Gaunt, TR, Charlotte Onland-Moret, N, Cooper, MN, Platou, CGP, Org, E, Hardy, R, Dahgam, S, Palmen, J, Vitart, V, Braund, PS, Kuznetsova, T, Uiterwaal, CSPM, Adeyemo, A, Palmas, W, Campbell, H, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, ND, Aspelund, T, Garcia, M, Chang, YPC, O'Connell, JR, Steinle, NI, Grobbee, DE, Arking, DE, Kardia, SL, Morrison, AC, Hernandez, D, Najjar, S, McArdle, WL, Hadley, D, Brown, MJ, Connell, JM, Hingorani, AD, Day, INM, Lawlor, DA, Beilby, JP, Lawrence, RW, Clarke, R, Hopewell, JC, Ongen, H, Dreisbach, AW, Li, Y, Hunter Young, J, Bis, JC, Kähönen, M, Viikari, J, Adair, LS, Lee, NR, Chen, MH, Olden, M, Pattaro, C, Bolton, JAH, Köttgen, A, Bergmann, S, Mooser, V, Chaturvedi, N, Frayling, TM, Islam, M, Jafar, TH, Erdmann, J, Kulkarni, SR, Bornstein, SR, Grässler, J, Groop, L, Voight, BF, Kettunen, J, Howard, P, Taylor, A, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Barroso, I, Khaw, KT, Weder, AB, Hunt, SC, Sun, YV, Bergman, RN, Collins, FS, Bonnycastle, LL, Scott, LJ, Stringham, HM, Peltonen, L, Perola, M, Vartiainen, E, Brand, SM, Staessen, JA, Wang, TJ, Burton, PR, Artigas, MS, Dong, Y, Snieder, H, Wang, X, Zhu, H, Lohman, KK, Rudock, ME, Heckbert, SR, Smith, NL, Wiggins, KL, Doumatey, A, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, D, Tripathy, V, Langefeld, CD, Rosengren, A, Thelle, DS, Corsi, AM, Singleton, A, Forrester, T, Hilton, G, McKenzie, CA, Salako, T, Iwai, N, Kita, Y, Ogihara, T, Ohkubo, T, Okamura, T, Ueshima, H, Umemura, S, Eyheramendy, S, Meitinger, T, Wichmann, HE, Cho, YS, Kim, HL, Lee, JY, Scott, J, Sehmi, JS, Zhang, W, Hedblad, B, Nilsson, P, Smith, GD, Wong, A, Narisu, N, Stančáková, A, Raffel, LJ, Yao, J, Kathiresan, S, O'Donnell, CJ, Schwartz, SM, Arfan Ikram, M, Longstreth, WT, Mosley, TH, Seshadri, S, Shrine, NRG, Wain, LV, Morken, MA, Swift, AJ, Laitinen, J, Prokopenko, I, Zitting, P, Cooper, JA, Humphries, SE, Danesh, J, Rasheed, A, Goel, A, Hamsten, A, Watkins, H, Bakker, SJL, van Gilst, WH, Janipalli, CS, Radha Mani, K, Yajnik, CS, Hofman, A, Mattace-Raso, FUS, Oostra, BA, Demirkan, A, Isaacs, A, Rivadeneira, F, Lakatta, EG, Orru, M, Scuteri, A, Ala-Korpela, M, Kangas, AJ, Lyytikäinen, LP, Soininen, P, Tukiainen, T, Würtz, P, Twee-HeeOng, R, Dörr, M, Kroemer, HK, Völker, U, Völzke, H, Galan, P, Hercberg, S, Lathrop, M, Zelenika, D, Deloukas, P, Mangino, M, Spector, TD, Zhai, G, Meschia, JF, Nalls, MA, Sharma, P, Terzic, J, Kranthi Kumar, MV, Denniff, M, Zukowska-Szczechowska, E, Wagenknecht, LE, Fowkes, FGR, Charchar, FJ, Schwarz, PEH, Hayward, C, Guo, X, Rotimi, C, Bots, ML, Brand, E, Samani, NJ, Polasek, O, Talmud, PJ, Nyberg, F, Kuh, D, Laan, M, Hveem, K, Palmer, LJ, van der Schouw, YT, Casas, JP, Mohlke, KL, Vineis, P, Raitakari, O, Ganesh, SK, Wong, TY, Shyong Tai, E, Cooper, RS, Laakso, M, Rao, DC, Harris, TB, Morris, RW, Dominiczak, AF, Kivimaki, M, Marmot, MG, Miki, T, Saleheen, D, Chandak, GR, Coresh, J, Navis, G, Salomaa, V, Han, BG, Zhu, X, Kooner, JS, Melander, O, Ridker, PM, Bandinelli, S, Gyllensten, UB, Wright, AF, Wilson, JF, Ferrucci, L, Farrall, M, Tuomilehto, J, Pramstaller, PP, Elosua, R, Soranzo, N, Sijbrands, EJG, Altshuler, D, Loos, RJF, Shuldiner, AR, Gieger, C, Meneton, P, Uitterlinden, AG, Wareham, NJ, Gudnason, V, Rotter, JI, Rettig, R, Uda, M, Strachan, DP, Witteman, JCM, Hartikainen, AL, Beckmann, JS, Boerwinkle, E, Vasan, RS, Boehnke, M, Larson, MG, Järvelin, MR, Psaty, BM, Abecasis, GR, Chakravarti, A, Elliott, P, van Duijn, CM, Newton-Cheh, C, Levy, D, Caulfield, MJ & Johnson, T 2011, 'Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk', Nature, vol. 478, no. 7367, pp. 103-109. https://doi.org/10.1038/nature10405
Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Oct 6;478(7367):103-109. https://doi.org/10.1038/nature10405
Ehret, Georg B. ; Munroe, Patricia B. ; Rice, Kenneth M. ; Bochud, Murielle ; Johnson, Andrew D. ; Chasman, Daniel I. ; Smith, Albert V. ; Tobin, Martin D. ; Verwoert, Germaine C. ; Hwang, Shih Jen ; Pihur, Vasyl ; Vollenweider, Peter ; O'Reilly, Paul F. ; Amin, Najaf ; Bragg-Gresham, Jennifer L. ; Teumer, Alexander ; Glazer, Nicole L. ; Launer, Lenore ; Zhao, Jing Hua ; Aulchenko, Yurii ; Heath, Simon ; Sober, Siim ; Parsa, Afshin ; Luan, Jian'an ; Arora, Pankaj ; Dehghan, Abbas ; Zhang, Feng ; Lucas, Gavin ; Hicks, Andrew A. ; Jackson, Anne U. ; Peden, John F. ; Tanaka, Toshiko ; Wild, Sarah H. ; Rudan, Igor ; Igl, Wilmar ; Milaneschi, Yuri ; Parker, Alex N. ; Fava, Cristiano ; Chambers, John C. ; Fox, Ervin R. ; Kumari, Meena ; Go, Min Jin ; van der Harst, Pim ; Kao, Wen Hong Linda ; Sjögren, Marketa ; Vinay, D. G. ; Alexander, Myriam ; Tabara, Yasuharu ; Shaw-Hawkins, Sue ; Whincup, Peter H. ; Liu, Yongmei ; Shi, Gang ; Kuusisto, Johanna ; Tayo, Bamidele ; Seielstad, Mark ; Sim, Xueling ; Hoang Nguyen, Khanh Dung ; Lehtimäki, Terho ; Matullo, Giuseppe ; Wu, Ying ; Gaunt, Tom R. ; Charlotte Onland-Moret, N. ; Cooper, Matthew N. ; Platou, Carl G.P. ; Org, Elin ; Hardy, Rebecca ; Dahgam, Santosh ; Palmen, Jutta ; Vitart, Veronique ; Braund, Peter S. ; Kuznetsova, Tatiana ; Uiterwaal, Cuno S.P.M. ; Adeyemo, Adebowale ; Palmas, Walter ; Campbell, Harry ; Ludwig, Barbara ; Tomaszewski, Maciej ; Tzoulaki, Ioanna ; Palmer, Nicholette D. ; Aspelund, Thor ; Garcia, Melissa ; Chang, Yen Pei C. ; O'Connell, Jeffrey R. ; Steinle, Nanette I. ; Grobbee, Diederick E. ; Arking, Dan E. ; Kardia, Sharon L. ; Morrison, Alanna C. ; Hernandez, Dena ; Najjar, Samer ; McArdle, Wendy L. ; Hadley, David ; Brown, Morris J. ; Connell, John M. ; Hingorani, Aroon D. ; Day, Ian N.M. ; Lawlor, Debbie A. ; Beilby, John P. ; Lawrence, Robert W. ; Clarke, Robert ; Hopewell, Jemma C. ; Ongen, Halit ; Dreisbach, Albert W. ; Li, Yali ; Hunter Young, J. ; Bis, Joshua C. ; Kähönen, Mika ; Viikari, Jorma ; Adair, Linda S. ; Lee, Nanette R. ; Chen, Ming Huei ; Olden, Matthias ; Pattaro, Cristian ; Bolton, Judith A.Hoffman ; Köttgen, Anna ; Bergmann, Sven ; Mooser, Vincent ; Chaturvedi, Nish ; Frayling, Timothy M. ; Islam, Muhammad ; Jafar, Tazeen H. ; Erdmann, Jeanette ; Kulkarni, Smita R. ; Bornstein, Stefan R. ; Grässler, Jürgen ; Groop, Leif ; Voight, Benjamin F. ; Kettunen, Johannes ; Howard, Philip ; Taylor, Andrew ; Guarrera, Simonetta ; Ricceri, Fulvio ; Emilsson, Valur ; Plump, Andrew ; Barroso, Inês ; Khaw, Kay Tee ; Weder, Alan B. ; Hunt, Steven C. ; Sun, Yan V. ; Bergman, Richard N. ; Collins, Francis S. ; Bonnycastle, Lori L. ; Scott, Laura J. ; Stringham, Heather M. ; Peltonen, Leena ; Perola, Markus ; Vartiainen, Erkki ; Brand, Stefan Martin ; Staessen, Jan A. ; Wang, Thomas J. ; Burton, Paul R. ; Artigas, Maria Soler ; Dong, Yanbin ; Snieder, Harold ; Wang, Xiaoling ; Zhu, Haidong ; Lohman, Kurt K. ; Rudock, Megan E. ; Heckbert, Susan R. ; Smith, Nicholas L. ; Wiggins, Kerri L. ; Doumatey, Ayo ; Shriner, Daniel ; Veldre, Gudrun ; Viigimaa, Margus ; Kinra, Sanjay ; Prabhakaran, Dorairaj ; Tripathy, Vikal ; Langefeld, Carl D. ; Rosengren, Annika ; Thelle, Dag S. ; Corsi, Anna Maria ; Singleton, Andrew ; Forrester, Terrence ; Hilton, Gina ; McKenzie, Colin A. ; Salako, Tunde ; Iwai, Naoharu ; Kita, Yoshikuni ; Ogihara, Toshio ; Ohkubo, Takayoshi ; Okamura, Tomonori ; Ueshima, Hirotsugu ; Umemura, Satoshi ; Eyheramendy, Susana ; Meitinger, Thomas ; Wichmann, H. Erich ; Cho, Yoon Shin ; Kim, Hyung Lae ; Lee, Jong Young ; Scott, James ; Sehmi, Joban S. ; Zhang, Weihua ; Hedblad, Bo ; Nilsson, Peter ; Smith, George Davey ; Wong, Andrew ; Narisu, Narisu ; Stančáková, Alena ; Raffel, Leslie J. ; Yao, Jie ; Kathiresan, Sekar ; O'Donnell, Christopher J. ; Schwartz, Stephen M. ; Arfan Ikram, M. ; Longstreth, W. T. ; Mosley, Thomas H. ; Seshadri, Sudha ; Shrine, Nick R.G. ; Wain, Louise V. ; Morken, Mario A. ; Swift, Amy J. ; Laitinen, Jaana ; Prokopenko, Inga ; Zitting, Paavo ; Cooper, Jackie A. ; Humphries, Steve E. ; Danesh, John ; Rasheed, Asif ; Goel, Anuj ; Hamsten, Anders ; Watkins, Hugh ; Bakker, Stephan J.L. ; van Gilst, Wiek H. ; Janipalli, Charles S. ; Radha Mani, K. ; Yajnik, Chittaranjan S. ; Hofman, Albert ; Mattace-Raso, Francesco U.S. ; Oostra, Ben A. ; Demirkan, Ayse ; Isaacs, Aaron ; Rivadeneira, Fernando ; Lakatta, Edward G. ; Orru, Marco ; Scuteri, Angelo ; Ala-Korpela, Mika ; Kangas, Antti J. ; Lyytikäinen, Leo Pekka ; Soininen, Pasi ; Tukiainen, Taru ; Würtz, Peter ; Twee-HeeOng, Rick ; Dörr, Marcus ; Kroemer, Heyo K. ; Völker, Uwe ; Völzke, Henry ; Galan, Pilar ; Hercberg, Serge ; Lathrop, Mark ; Zelenika, Diana ; Deloukas, Panos ; Mangino, Massimo ; Spector, Tim D. ; Zhai, Guangju ; Meschia, James F. ; Nalls, Michael A. ; Sharma, Pankaj ; Terzic, Janos ; Kranthi Kumar, M. V. ; Denniff, Matthew ; Zukowska-Szczechowska, Ewa ; Wagenknecht, Lynne E. ; Fowkes, F. Gerald R. ; Charchar, Fadi J. ; Schwarz, Peter E.H. ; Hayward, Caroline ; Guo, Xiuqing ; Rotimi, Charles ; Bots, Michiel L. ; Brand, Eva ; Samani, Nilesh J. ; Polasek, Ozren ; Talmud, Philippa J. ; Nyberg, Fredrik ; Kuh, Diana ; Laan, Maris ; Hveem, Kristian ; Palmer, Lyle J. ; van der Schouw, Yvonne T. ; Casas, Juan P. ; Mohlke, Karen L. ; Vineis, Paolo ; Raitakari, Olli ; Ganesh, Santhi K. ; Wong, Tien Y. ; Shyong Tai, E. ; Cooper, Richard S. ; Laakso, Markku ; Rao, Dabeeru C. ; Harris, Tamara B. ; Morris, Richard W. ; Dominiczak, Anna F. ; Kivimaki, Mika ; Marmot, Michael G. ; Miki, Tetsuro ; Saleheen, Danish ; Chandak, Giriraj R. ; Coresh, Josef ; Navis, Gerjan ; Salomaa, Veikko ; Han, Bok Ghee ; Zhu, Xiaofeng ; Kooner, Jaspal S. ; Melander, Olle ; Ridker, Paul M. ; Bandinelli, Stefania ; Gyllensten, Ulf B. ; Wright, Alan F. ; Wilson, James F. ; Ferrucci, Luigi ; Farrall, Martin ; Tuomilehto, Jaakko ; Pramstaller, Peter P. ; Elosua, Roberto ; Soranzo, Nicole ; Sijbrands, Eric J.G. ; Altshuler, David ; Loos, Ruth J.F. ; Shuldiner, Alan R. ; Gieger, Christian ; Meneton, Pierre ; Uitterlinden, Andre G. ; Wareham, Nicholas J. ; Gudnason, Vilmundur ; Rotter, Jerome I. ; Rettig, Rainer ; Uda, Manuela ; Strachan, David P. ; Witteman, Jacqueline C.M. ; Hartikainen, Anna Liisa ; Beckmann, Jacques S. ; Boerwinkle, Eric ; Vasan, Ramachandran S. ; Boehnke, Michael ; Larson, Martin G. ; Järvelin, Marjo Riitta ; Psaty, Bruce M. ; Abecasis, Gonçalo R. ; Chakravarti, Aravinda ; Elliott, Paul ; van Duijn, Cornelia M. ; Newton-Cheh, Christopher ; Levy, Daniel ; Caulfield, Mark J. ; Johnson, Toby. / Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. In: Nature. 2011 ; Vol. 478, No. 7367. pp. 103-109.
@article{b1a87e6f713845ee9108e757b2b1406f,
title = "Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk",
abstract = "Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140mmg Hg systolic blood pressure ≥90mmg Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3 GUCY1B3, NPR3 C5orf23, ADM, FURIN FES, GOSR2, GNAS EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.",
author = "Ehret, {Georg B.} and Munroe, {Patricia B.} and Rice, {Kenneth M.} and Murielle Bochud and Johnson, {Andrew D.} and Chasman, {Daniel I.} and Smith, {Albert V.} and Tobin, {Martin D.} and Verwoert, {Germaine C.} and Hwang, {Shih Jen} and Vasyl Pihur and Peter Vollenweider and O'Reilly, {Paul F.} and Najaf Amin and Bragg-Gresham, {Jennifer L.} and Alexander Teumer and Glazer, {Nicole L.} and Lenore Launer and Zhao, {Jing Hua} and Yurii Aulchenko and Simon Heath and Siim Sober and Afshin Parsa and Jian'an Luan and Pankaj Arora and Abbas Dehghan and Feng Zhang and Gavin Lucas and Hicks, {Andrew A.} and Jackson, {Anne U.} and Peden, {John F.} and Toshiko Tanaka and Wild, {Sarah H.} and Igor Rudan and Wilmar Igl and Yuri Milaneschi and Parker, {Alex N.} and Cristiano Fava and Chambers, {John C.} and Fox, {Ervin R.} and Meena Kumari and Go, {Min Jin} and {van der Harst}, Pim and Kao, {Wen Hong Linda} and Marketa Sj{\"o}gren and Vinay, {D. G.} and Myriam Alexander and Yasuharu Tabara and Sue Shaw-Hawkins and Whincup, {Peter H.} and Yongmei Liu and Gang Shi and Johanna Kuusisto and Bamidele Tayo and Mark Seielstad and Xueling Sim and {Hoang Nguyen}, {Khanh Dung} and Terho Lehtim{\"a}ki and Giuseppe Matullo and Ying Wu and Gaunt, {Tom R.} and {Charlotte Onland-Moret}, N. and Cooper, {Matthew N.} and Platou, {Carl G.P.} and Elin Org and Rebecca Hardy and Santosh Dahgam and Jutta Palmen and Veronique Vitart and Braund, {Peter S.} and Tatiana Kuznetsova and Uiterwaal, {Cuno S.P.M.} and Adebowale Adeyemo and Walter Palmas and Harry Campbell and Barbara Ludwig and Maciej Tomaszewski and Ioanna Tzoulaki and Palmer, {Nicholette D.} and Thor Aspelund and Melissa Garcia and Chang, {Yen Pei C.} and O'Connell, {Jeffrey R.} and Steinle, {Nanette I.} and Grobbee, {Diederick E.} and Arking, {Dan E.} and Kardia, {Sharon L.} and Morrison, {Alanna C.} and Dena Hernandez and Samer Najjar and McArdle, {Wendy L.} and David Hadley and Brown, {Morris J.} and Connell, {John M.} and Hingorani, {Aroon D.} and Day, {Ian N.M.} and Lawlor, {Debbie A.} and Beilby, {John P.} and Lawrence, {Robert W.} and Robert Clarke and Hopewell, {Jemma C.} and Halit Ongen and Dreisbach, {Albert W.} and Yali Li and {Hunter Young}, J. and Bis, {Joshua C.} and Mika K{\"a}h{\"o}nen and Jorma Viikari and Adair, {Linda S.} and Lee, {Nanette R.} and Chen, {Ming Huei} and Matthias Olden and Cristian Pattaro and Bolton, {Judith A.Hoffman} and Anna K{\"o}ttgen and Sven Bergmann and Vincent Mooser and Nish Chaturvedi and Frayling, {Timothy M.} and Muhammad Islam and Jafar, {Tazeen H.} and Jeanette Erdmann and Kulkarni, {Smita R.} and Bornstein, {Stefan R.} and J{\"u}rgen Gr{\"a}ssler and Leif Groop and Voight, {Benjamin F.} and Johannes Kettunen and Philip Howard and Andrew Taylor and Simonetta Guarrera and Fulvio Ricceri and Valur Emilsson and Andrew Plump and In{\^e}s Barroso and Khaw, {Kay Tee} and Weder, {Alan B.} and Hunt, {Steven C.} and Sun, {Yan V.} and Bergman, {Richard N.} and Collins, {Francis S.} and Bonnycastle, {Lori L.} and Scott, {Laura J.} and Stringham, {Heather M.} and Leena Peltonen and Markus Perola and Erkki Vartiainen and Brand, {Stefan Martin} and Staessen, {Jan A.} and Wang, {Thomas J.} and Burton, {Paul R.} and Artigas, {Maria Soler} and Yanbin Dong and Harold Snieder and Xiaoling Wang and Haidong Zhu and Lohman, {Kurt K.} and Rudock, {Megan E.} and Heckbert, {Susan R.} and Smith, {Nicholas L.} and Wiggins, {Kerri L.} and Ayo Doumatey and Daniel Shriner and Gudrun Veldre and Margus Viigimaa and Sanjay Kinra and Dorairaj Prabhakaran and Vikal Tripathy and Langefeld, {Carl D.} and Annika Rosengren and Thelle, {Dag S.} and Corsi, {Anna Maria} and Andrew Singleton and Terrence Forrester and Gina Hilton and McKenzie, {Colin A.} and Tunde Salako and Naoharu Iwai and Yoshikuni Kita and Toshio Ogihara and Takayoshi Ohkubo and Tomonori Okamura and Hirotsugu Ueshima and Satoshi Umemura and Susana Eyheramendy and Thomas Meitinger and Wichmann, {H. Erich} and Cho, {Yoon Shin} and Kim, {Hyung Lae} and Lee, {Jong Young} and James Scott and Sehmi, {Joban S.} and Weihua Zhang and Bo Hedblad and Peter Nilsson and Smith, {George Davey} and Andrew Wong and Narisu Narisu and Alena Stanč{\'a}kov{\'a} and Raffel, {Leslie J.} and Jie Yao and Sekar Kathiresan and O'Donnell, {Christopher J.} and Schwartz, {Stephen M.} and {Arfan Ikram}, M. and Longstreth, {W. T.} and Mosley, {Thomas H.} and Sudha Seshadri and Shrine, {Nick R.G.} and Wain, {Louise V.} and Morken, {Mario A.} and Swift, {Amy J.} and Jaana Laitinen and Inga Prokopenko and Paavo Zitting and Cooper, {Jackie A.} and Humphries, {Steve E.} and John Danesh and Asif Rasheed and Anuj Goel and Anders Hamsten and Hugh Watkins and Bakker, {Stephan J.L.} and {van Gilst}, {Wiek H.} and Janipalli, {Charles S.} and {Radha Mani}, K. and Yajnik, {Chittaranjan S.} and Albert Hofman and Mattace-Raso, {Francesco U.S.} and Oostra, {Ben A.} and Ayse Demirkan and Aaron Isaacs and Fernando Rivadeneira and Lakatta, {Edward G.} and Marco Orru and Angelo Scuteri and Mika Ala-Korpela and Kangas, {Antti J.} and Lyytik{\"a}inen, {Leo Pekka} and Pasi Soininen and Taru Tukiainen and Peter W{\"u}rtz and Rick Twee-HeeOng and Marcus D{\"o}rr and Kroemer, {Heyo K.} and Uwe V{\"o}lker and Henry V{\"o}lzke and Pilar Galan and Serge Hercberg and Mark Lathrop and Diana Zelenika and Panos Deloukas and Massimo Mangino and Spector, {Tim D.} and Guangju Zhai and Meschia, {James F.} and Nalls, {Michael A.} and Pankaj Sharma and Janos Terzic and {Kranthi Kumar}, {M. V.} and Matthew Denniff and Ewa Zukowska-Szczechowska and Wagenknecht, {Lynne E.} and Fowkes, {F. Gerald R.} and Charchar, {Fadi J.} and Schwarz, {Peter E.H.} and Caroline Hayward and Xiuqing Guo and Charles Rotimi and Bots, {Michiel L.} and Eva Brand and Samani, {Nilesh J.} and Ozren Polasek and Talmud, {Philippa J.} and Fredrik Nyberg and Diana Kuh and Maris Laan and Kristian Hveem and Palmer, {Lyle J.} and {van der Schouw}, {Yvonne T.} and Casas, {Juan P.} and Mohlke, {Karen L.} and Paolo Vineis and Olli Raitakari and Ganesh, {Santhi K.} and Wong, {Tien Y.} and {Shyong Tai}, E. and Cooper, {Richard S.} and Markku Laakso and Rao, {Dabeeru C.} and Harris, {Tamara B.} and Morris, {Richard W.} and Dominiczak, {Anna F.} and Mika Kivimaki and Marmot, {Michael G.} and Tetsuro Miki and Danish Saleheen and Chandak, {Giriraj R.} and Josef Coresh and Gerjan Navis and Veikko Salomaa and Han, {Bok Ghee} and Xiaofeng Zhu and Kooner, {Jaspal S.} and Olle Melander and Ridker, {Paul M.} and Stefania Bandinelli and Gyllensten, {Ulf B.} and Wright, {Alan F.} and Wilson, {James F.} and Luigi Ferrucci and Martin Farrall and Jaakko Tuomilehto and Pramstaller, {Peter P.} and Roberto Elosua and Nicole Soranzo and Sijbrands, {Eric J.G.} and David Altshuler and Loos, {Ruth J.F.} and Shuldiner, {Alan R.} and Christian Gieger and Pierre Meneton and Uitterlinden, {Andre G.} and Wareham, {Nicholas J.} and Vilmundur Gudnason and Rotter, {Jerome I.} and Rainer Rettig and Manuela Uda and Strachan, {David P.} and Witteman, {Jacqueline C.M.} and Hartikainen, {Anna Liisa} and Beckmann, {Jacques S.} and Eric Boerwinkle and Vasan, {Ramachandran S.} and Michael Boehnke and Larson, {Martin G.} and J{\"a}rvelin, {Marjo Riitta} and Psaty, {Bruce M.} and Abecasis, {Gon{\cc}alo R.} and Aravinda Chakravarti and Paul Elliott and {van Duijn}, {Cornelia M.} and Christopher Newton-Cheh and Daniel Levy and Caulfield, {Mark J.} and Toby Johnson",
year = "2011",
month = "10",
day = "6",
doi = "10.1038/nature10405",
language = "English (US)",
volume = "478",
pages = "103--109",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7367",

}

TY - JOUR

T1 - Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

AU - Ehret, Georg B.

AU - Munroe, Patricia B.

AU - Rice, Kenneth M.

AU - Bochud, Murielle

AU - Johnson, Andrew D.

AU - Chasman, Daniel I.

AU - Smith, Albert V.

AU - Tobin, Martin D.

AU - Verwoert, Germaine C.

AU - Hwang, Shih Jen

AU - Pihur, Vasyl

AU - Vollenweider, Peter

AU - O'Reilly, Paul F.

AU - Amin, Najaf

AU - Bragg-Gresham, Jennifer L.

AU - Teumer, Alexander

AU - Glazer, Nicole L.

AU - Launer, Lenore

AU - Zhao, Jing Hua

AU - Aulchenko, Yurii

AU - Heath, Simon

AU - Sober, Siim

AU - Parsa, Afshin

AU - Luan, Jian'an

AU - Arora, Pankaj

AU - Dehghan, Abbas

AU - Zhang, Feng

AU - Lucas, Gavin

AU - Hicks, Andrew A.

AU - Jackson, Anne U.

AU - Peden, John F.

AU - Tanaka, Toshiko

AU - Wild, Sarah H.

AU - Rudan, Igor

AU - Igl, Wilmar

AU - Milaneschi, Yuri

AU - Parker, Alex N.

AU - Fava, Cristiano

AU - Chambers, John C.

AU - Fox, Ervin R.

AU - Kumari, Meena

AU - Go, Min Jin

AU - van der Harst, Pim

AU - Kao, Wen Hong Linda

AU - Sjögren, Marketa

AU - Vinay, D. G.

AU - Alexander, Myriam

AU - Tabara, Yasuharu

AU - Shaw-Hawkins, Sue

AU - Whincup, Peter H.

AU - Liu, Yongmei

AU - Shi, Gang

AU - Kuusisto, Johanna

AU - Tayo, Bamidele

AU - Seielstad, Mark

AU - Sim, Xueling

AU - Hoang Nguyen, Khanh Dung

AU - Lehtimäki, Terho

AU - Matullo, Giuseppe

AU - Wu, Ying

AU - Gaunt, Tom R.

AU - Charlotte Onland-Moret, N.

AU - Cooper, Matthew N.

AU - Platou, Carl G.P.

AU - Org, Elin

AU - Hardy, Rebecca

AU - Dahgam, Santosh

AU - Palmen, Jutta

AU - Vitart, Veronique

AU - Braund, Peter S.

AU - Kuznetsova, Tatiana

AU - Uiterwaal, Cuno S.P.M.

AU - Adeyemo, Adebowale

AU - Palmas, Walter

AU - Campbell, Harry

AU - Ludwig, Barbara

AU - Tomaszewski, Maciej

AU - Tzoulaki, Ioanna

AU - Palmer, Nicholette D.

AU - Aspelund, Thor

AU - Garcia, Melissa

AU - Chang, Yen Pei C.

AU - O'Connell, Jeffrey R.

AU - Steinle, Nanette I.

AU - Grobbee, Diederick E.

AU - Arking, Dan E.

AU - Kardia, Sharon L.

AU - Morrison, Alanna C.

AU - Hernandez, Dena

AU - Najjar, Samer

AU - McArdle, Wendy L.

AU - Hadley, David

AU - Brown, Morris J.

AU - Connell, John M.

AU - Hingorani, Aroon D.

AU - Day, Ian N.M.

AU - Lawlor, Debbie A.

AU - Beilby, John P.

AU - Lawrence, Robert W.

AU - Clarke, Robert

AU - Hopewell, Jemma C.

AU - Ongen, Halit

AU - Dreisbach, Albert W.

AU - Li, Yali

AU - Hunter Young, J.

AU - Bis, Joshua C.

AU - Kähönen, Mika

AU - Viikari, Jorma

AU - Adair, Linda S.

AU - Lee, Nanette R.

AU - Chen, Ming Huei

AU - Olden, Matthias

AU - Pattaro, Cristian

AU - Bolton, Judith A.Hoffman

AU - Köttgen, Anna

AU - Bergmann, Sven

AU - Mooser, Vincent

AU - Chaturvedi, Nish

AU - Frayling, Timothy M.

AU - Islam, Muhammad

AU - Jafar, Tazeen H.

AU - Erdmann, Jeanette

AU - Kulkarni, Smita R.

AU - Bornstein, Stefan R.

AU - Grässler, Jürgen

AU - Groop, Leif

AU - Voight, Benjamin F.

AU - Kettunen, Johannes

AU - Howard, Philip

AU - Taylor, Andrew

AU - Guarrera, Simonetta

AU - Ricceri, Fulvio

AU - Emilsson, Valur

AU - Plump, Andrew

AU - Barroso, Inês

AU - Khaw, Kay Tee

AU - Weder, Alan B.

AU - Hunt, Steven C.

AU - Sun, Yan V.

AU - Bergman, Richard N.

AU - Collins, Francis S.

AU - Bonnycastle, Lori L.

AU - Scott, Laura J.

AU - Stringham, Heather M.

AU - Peltonen, Leena

AU - Perola, Markus

AU - Vartiainen, Erkki

AU - Brand, Stefan Martin

AU - Staessen, Jan A.

AU - Wang, Thomas J.

AU - Burton, Paul R.

AU - Artigas, Maria Soler

AU - Dong, Yanbin

AU - Snieder, Harold

AU - Wang, Xiaoling

AU - Zhu, Haidong

AU - Lohman, Kurt K.

AU - Rudock, Megan E.

AU - Heckbert, Susan R.

AU - Smith, Nicholas L.

AU - Wiggins, Kerri L.

AU - Doumatey, Ayo

AU - Shriner, Daniel

AU - Veldre, Gudrun

AU - Viigimaa, Margus

AU - Kinra, Sanjay

AU - Prabhakaran, Dorairaj

AU - Tripathy, Vikal

AU - Langefeld, Carl D.

AU - Rosengren, Annika

AU - Thelle, Dag S.

AU - Corsi, Anna Maria

AU - Singleton, Andrew

AU - Forrester, Terrence

AU - Hilton, Gina

AU - McKenzie, Colin A.

AU - Salako, Tunde

AU - Iwai, Naoharu

AU - Kita, Yoshikuni

AU - Ogihara, Toshio

AU - Ohkubo, Takayoshi

AU - Okamura, Tomonori

AU - Ueshima, Hirotsugu

AU - Umemura, Satoshi

AU - Eyheramendy, Susana

AU - Meitinger, Thomas

AU - Wichmann, H. Erich

AU - Cho, Yoon Shin

AU - Kim, Hyung Lae

AU - Lee, Jong Young

AU - Scott, James

AU - Sehmi, Joban S.

AU - Zhang, Weihua

AU - Hedblad, Bo

AU - Nilsson, Peter

AU - Smith, George Davey

AU - Wong, Andrew

AU - Narisu, Narisu

AU - Stančáková, Alena

AU - Raffel, Leslie J.

AU - Yao, Jie

AU - Kathiresan, Sekar

AU - O'Donnell, Christopher J.

AU - Schwartz, Stephen M.

AU - Arfan Ikram, M.

AU - Longstreth, W. T.

AU - Mosley, Thomas H.

AU - Seshadri, Sudha

AU - Shrine, Nick R.G.

AU - Wain, Louise V.

AU - Morken, Mario A.

AU - Swift, Amy J.

AU - Laitinen, Jaana

AU - Prokopenko, Inga

AU - Zitting, Paavo

AU - Cooper, Jackie A.

AU - Humphries, Steve E.

AU - Danesh, John

AU - Rasheed, Asif

AU - Goel, Anuj

AU - Hamsten, Anders

AU - Watkins, Hugh

AU - Bakker, Stephan J.L.

AU - van Gilst, Wiek H.

AU - Janipalli, Charles S.

AU - Radha Mani, K.

AU - Yajnik, Chittaranjan S.

AU - Hofman, Albert

AU - Mattace-Raso, Francesco U.S.

AU - Oostra, Ben A.

AU - Demirkan, Ayse

AU - Isaacs, Aaron

AU - Rivadeneira, Fernando

AU - Lakatta, Edward G.

AU - Orru, Marco

AU - Scuteri, Angelo

AU - Ala-Korpela, Mika

AU - Kangas, Antti J.

AU - Lyytikäinen, Leo Pekka

AU - Soininen, Pasi

AU - Tukiainen, Taru

AU - Würtz, Peter

AU - Twee-HeeOng, Rick

AU - Dörr, Marcus

AU - Kroemer, Heyo K.

AU - Völker, Uwe

AU - Völzke, Henry

AU - Galan, Pilar

AU - Hercberg, Serge

AU - Lathrop, Mark

AU - Zelenika, Diana

AU - Deloukas, Panos

AU - Mangino, Massimo

AU - Spector, Tim D.

AU - Zhai, Guangju

AU - Meschia, James F.

AU - Nalls, Michael A.

AU - Sharma, Pankaj

AU - Terzic, Janos

AU - Kranthi Kumar, M. V.

AU - Denniff, Matthew

AU - Zukowska-Szczechowska, Ewa

AU - Wagenknecht, Lynne E.

AU - Fowkes, F. Gerald R.

AU - Charchar, Fadi J.

AU - Schwarz, Peter E.H.

AU - Hayward, Caroline

AU - Guo, Xiuqing

AU - Rotimi, Charles

AU - Bots, Michiel L.

AU - Brand, Eva

AU - Samani, Nilesh J.

AU - Polasek, Ozren

AU - Talmud, Philippa J.

AU - Nyberg, Fredrik

AU - Kuh, Diana

AU - Laan, Maris

AU - Hveem, Kristian

AU - Palmer, Lyle J.

AU - van der Schouw, Yvonne T.

AU - Casas, Juan P.

AU - Mohlke, Karen L.

AU - Vineis, Paolo

AU - Raitakari, Olli

AU - Ganesh, Santhi K.

AU - Wong, Tien Y.

AU - Shyong Tai, E.

AU - Cooper, Richard S.

AU - Laakso, Markku

AU - Rao, Dabeeru C.

AU - Harris, Tamara B.

AU - Morris, Richard W.

AU - Dominiczak, Anna F.

AU - Kivimaki, Mika

AU - Marmot, Michael G.

AU - Miki, Tetsuro

AU - Saleheen, Danish

AU - Chandak, Giriraj R.

AU - Coresh, Josef

AU - Navis, Gerjan

AU - Salomaa, Veikko

AU - Han, Bok Ghee

AU - Zhu, Xiaofeng

AU - Kooner, Jaspal S.

AU - Melander, Olle

AU - Ridker, Paul M.

AU - Bandinelli, Stefania

AU - Gyllensten, Ulf B.

AU - Wright, Alan F.

AU - Wilson, James F.

AU - Ferrucci, Luigi

AU - Farrall, Martin

AU - Tuomilehto, Jaakko

AU - Pramstaller, Peter P.

AU - Elosua, Roberto

AU - Soranzo, Nicole

AU - Sijbrands, Eric J.G.

AU - Altshuler, David

AU - Loos, Ruth J.F.

AU - Shuldiner, Alan R.

AU - Gieger, Christian

AU - Meneton, Pierre

AU - Uitterlinden, Andre G.

AU - Wareham, Nicholas J.

AU - Gudnason, Vilmundur

AU - Rotter, Jerome I.

AU - Rettig, Rainer

AU - Uda, Manuela

AU - Strachan, David P.

AU - Witteman, Jacqueline C.M.

AU - Hartikainen, Anna Liisa

AU - Beckmann, Jacques S.

AU - Boerwinkle, Eric

AU - Vasan, Ramachandran S.

AU - Boehnke, Michael

AU - Larson, Martin G.

AU - Järvelin, Marjo Riitta

AU - Psaty, Bruce M.

AU - Abecasis, Gonçalo R.

AU - Chakravarti, Aravinda

AU - Elliott, Paul

AU - van Duijn, Cornelia M.

AU - Newton-Cheh, Christopher

AU - Levy, Daniel

AU - Caulfield, Mark J.

AU - Johnson, Toby

PY - 2011/10/6

Y1 - 2011/10/6

N2 - Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140mmg Hg systolic blood pressure ≥90mmg Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3 GUCY1B3, NPR3 C5orf23, ADM, FURIN FES, GOSR2, GNAS EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

AB - Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140mmg Hg systolic blood pressure ≥90mmg Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3 GUCY1B3, NPR3 C5orf23, ADM, FURIN FES, GOSR2, GNAS EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

UR - http://www.scopus.com/inward/record.url?scp=80053907554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053907554&partnerID=8YFLogxK

U2 - 10.1038/nature10405

DO - 10.1038/nature10405

M3 - Article

VL - 478

SP - 103

EP - 109

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7367

ER -