TY - JOUR
T1 - Genetic variants and susceptibility to neurological complications following West Nile virus infection
AU - Loeb, Mark
AU - Eskandarian, Sasha
AU - Rupp, Mark
AU - Fishman, Neil
AU - Gasink, Leanne
AU - Patterson, Jan
AU - Bramson, Jonathan
AU - Hudson, Thomas J.
AU - Lemire, Mathieu
N1 - Funding Information:
This work was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (contract HHSN266200400066C).
PY - 2011/10/1
Y1 - 2011/10/1
N2 - To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P= 1.88×10-5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56-.81]); rs2298771 in SCN1A (sodium channel, neuronal type I a subunit) (P = 5.87 × 10-5; OR, 1.47 [95% CI, 1.21-1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10-4; OR, 0.69 [95% CI, .56-.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.
AB - To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P= 1.88×10-5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56-.81]); rs2298771 in SCN1A (sodium channel, neuronal type I a subunit) (P = 5.87 × 10-5; OR, 1.47 [95% CI, 1.21-1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10-4; OR, 0.69 [95% CI, .56-.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.
UR - https://www.scopus.com/pages/publications/80052425321
UR - https://www.scopus.com/pages/publications/80052425321#tab=citedBy
U2 - 10.1093/infdis/jir493
DO - 10.1093/infdis/jir493
M3 - Article
C2 - 21881118
AN - SCOPUS:80052425321
SN - 0022-1899
VL - 204
SP - 1031
EP - 1037
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -