Genetic susceptibility to pre-eclampsia and chromosome 7q36

Guanglan Guo, Jennifer A. Lade, Alan N. Wilton, Eric K. Moses, Madonna Grehan, Yuliang Fu, Hongyu Qiu, Desmond W. Cooper, Shaun P. Brennecke

    Research output: Contribution to journalArticle

    44 Scopus citations

    Abstract

    Pre-eclampsia is the most common serious medical disorder of human pregnancy. The human endothelial cell nitric oxide synthase (eNOS) gene is a candidate for pre-eclampsia/eclampsia (PE/E) susceptibility. A linkage study was performed on Australian PE/E families using 25 microsatellite markers from chromosome 7, one of which (eNOS-CA) resides within the eNOS gene. No significant linkage was found for the eNOS-CA marker using either parametric or non-parametric analysis. However, D7S1805 from the eNOS gene region on 7q36, gave a suggestion of linkage using parametric analysis (maximum LOD score = 2.143 at θ = 0.14) and non-parametric APM analysis (T(1/sqrt(p)) = 3.53; P = 0.002). Further, an association study was performed on unrelated PE/E cases and controls from both Chinese and Australian populations to test for a relationship between the eNOS gene and PE/E. No association was found between the eNOS-CA marker and PE/E in either population. However, there was a significant difference in the allelic distribution of eNOS-CA between the two ethnic groups. The linkage results support the possibility that a susceptibility locus for preeclampsia resides in the 7q36 region, however, there is no definitive evidence to support the notion that the eNOS gene itself is responsible for susceptibility to pre-eclampsia.

    Original languageEnglish (US)
    Pages (from-to)641-647
    Number of pages7
    JournalHuman Genetics
    Volume105
    Issue number6
    DOIs
    StatePublished - Jan 1 1999

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

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  • Cite this

    Guo, G., Lade, J. A., Wilton, A. N., Moses, E. K., Grehan, M., Fu, Y., Qiu, H., Cooper, D. W., & Brennecke, S. P. (1999). Genetic susceptibility to pre-eclampsia and chromosome 7q36. Human Genetics, 105(6), 641-647. https://doi.org/10.1007/s004399900172