Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder

Elizabeth Hare, Javier Contreras, Henriette Raventos, Deborah Flores, Alvaro Jerez, Humberto Nicolini, Alfonso Ontiveros, Laura Almasy, Michael Escamilla

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. Methods: The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Results: Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I), the intermediate phenotype (schizoaffective bipolar, bipolar I, and bipolar II), and the broadest phenotype (schizoaffective bipolar, bipolar I, bipolar II, and recurrent depression), respectively. For the Big Five personality factors, heritabilities were 0.25 for agreeableness, 0.24 for conscientiousness, 0.24 for extraversion, 0.23 for neuroticism, and 0.32 for openness to experience. For the narrowest phenotype, a significant negative correlation (- 0.32) with extraversion was found. For the broadest phenotype, negative correlations were found for agreeableness (- 0.35), conscientiousness (- 0.39), and extraversion (- 0.44). A positive correlation (0.37) was found with neuroticism. Limitations: It is not possible to determine whether aspects of personality are factors in the development of bipolar disorder or vice versa. The short form of the NEO does not provide the ability to examine in detail which facets of extraversion are most closely related to bipolar disorder or to compare our results with studies that have used the long version of the scale. Conclusions: This study establishes a partial genetic basis for the Big Five personality factors in this set of families, while the environmental variances demonstrate that non-genetic factors are also important in their influence on bipolar and personality phenotypes. BPD may be most associated with decreased extraversion (less interaction with one's surroundings) because patients spend more time in depressive than manic states.

Original languageEnglish (US)
Pages (from-to)1027-1033
Number of pages7
JournalJournal of Affective Disorders
Volume136
Issue number3
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Genetic Structures
Personality Disorders
Bipolar Disorder
Personality
Phenotype
Aptitude
Software
Extraversion (Psychology)
Depression

Keywords

  • Bipolar disorder
  • Extraversion
  • Genetic correlation
  • Heritability
  • Personality

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Hare, E., Contreras, J., Raventos, H., Flores, D., Jerez, A., Nicolini, H., ... Escamilla, M. (2012). Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder. Journal of Affective Disorders, 136(3), 1027-1033. https://doi.org/10.1016/j.jad.2011.04.057

Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder. / Hare, Elizabeth; Contreras, Javier; Raventos, Henriette; Flores, Deborah; Jerez, Alvaro; Nicolini, Humberto; Ontiveros, Alfonso; Almasy, Laura; Escamilla, Michael.

In: Journal of Affective Disorders, Vol. 136, No. 3, 02.2012, p. 1027-1033.

Research output: Contribution to journalArticle

Hare, E, Contreras, J, Raventos, H, Flores, D, Jerez, A, Nicolini, H, Ontiveros, A, Almasy, L & Escamilla, M 2012, 'Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder', Journal of Affective Disorders, vol. 136, no. 3, pp. 1027-1033. https://doi.org/10.1016/j.jad.2011.04.057
Hare, Elizabeth ; Contreras, Javier ; Raventos, Henriette ; Flores, Deborah ; Jerez, Alvaro ; Nicolini, Humberto ; Ontiveros, Alfonso ; Almasy, Laura ; Escamilla, Michael. / Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder. In: Journal of Affective Disorders. 2012 ; Vol. 136, No. 3. pp. 1027-1033.
@article{60075cec10df486687dd926dfe461a72,
title = "Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder",
abstract = "Background: Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. Methods: The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Results: Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I), the intermediate phenotype (schizoaffective bipolar, bipolar I, and bipolar II), and the broadest phenotype (schizoaffective bipolar, bipolar I, bipolar II, and recurrent depression), respectively. For the Big Five personality factors, heritabilities were 0.25 for agreeableness, 0.24 for conscientiousness, 0.24 for extraversion, 0.23 for neuroticism, and 0.32 for openness to experience. For the narrowest phenotype, a significant negative correlation (- 0.32) with extraversion was found. For the broadest phenotype, negative correlations were found for agreeableness (- 0.35), conscientiousness (- 0.39), and extraversion (- 0.44). A positive correlation (0.37) was found with neuroticism. Limitations: It is not possible to determine whether aspects of personality are factors in the development of bipolar disorder or vice versa. The short form of the NEO does not provide the ability to examine in detail which facets of extraversion are most closely related to bipolar disorder or to compare our results with studies that have used the long version of the scale. Conclusions: This study establishes a partial genetic basis for the Big Five personality factors in this set of families, while the environmental variances demonstrate that non-genetic factors are also important in their influence on bipolar and personality phenotypes. BPD may be most associated with decreased extraversion (less interaction with one's surroundings) because patients spend more time in depressive than manic states.",
keywords = "Bipolar disorder, Extraversion, Genetic correlation, Heritability, Personality",
author = "Elizabeth Hare and Javier Contreras and Henriette Raventos and Deborah Flores and Alvaro Jerez and Humberto Nicolini and Alfonso Ontiveros and Laura Almasy and Michael Escamilla",
year = "2012",
month = "2",
doi = "10.1016/j.jad.2011.04.057",
language = "English (US)",
volume = "136",
pages = "1027--1033",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder

AU - Hare, Elizabeth

AU - Contreras, Javier

AU - Raventos, Henriette

AU - Flores, Deborah

AU - Jerez, Alvaro

AU - Nicolini, Humberto

AU - Ontiveros, Alfonso

AU - Almasy, Laura

AU - Escamilla, Michael

PY - 2012/2

Y1 - 2012/2

N2 - Background: Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. Methods: The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Results: Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I), the intermediate phenotype (schizoaffective bipolar, bipolar I, and bipolar II), and the broadest phenotype (schizoaffective bipolar, bipolar I, bipolar II, and recurrent depression), respectively. For the Big Five personality factors, heritabilities were 0.25 for agreeableness, 0.24 for conscientiousness, 0.24 for extraversion, 0.23 for neuroticism, and 0.32 for openness to experience. For the narrowest phenotype, a significant negative correlation (- 0.32) with extraversion was found. For the broadest phenotype, negative correlations were found for agreeableness (- 0.35), conscientiousness (- 0.39), and extraversion (- 0.44). A positive correlation (0.37) was found with neuroticism. Limitations: It is not possible to determine whether aspects of personality are factors in the development of bipolar disorder or vice versa. The short form of the NEO does not provide the ability to examine in detail which facets of extraversion are most closely related to bipolar disorder or to compare our results with studies that have used the long version of the scale. Conclusions: This study establishes a partial genetic basis for the Big Five personality factors in this set of families, while the environmental variances demonstrate that non-genetic factors are also important in their influence on bipolar and personality phenotypes. BPD may be most associated with decreased extraversion (less interaction with one's surroundings) because patients spend more time in depressive than manic states.

AB - Background: Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. Methods: The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Results: Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I), the intermediate phenotype (schizoaffective bipolar, bipolar I, and bipolar II), and the broadest phenotype (schizoaffective bipolar, bipolar I, bipolar II, and recurrent depression), respectively. For the Big Five personality factors, heritabilities were 0.25 for agreeableness, 0.24 for conscientiousness, 0.24 for extraversion, 0.23 for neuroticism, and 0.32 for openness to experience. For the narrowest phenotype, a significant negative correlation (- 0.32) with extraversion was found. For the broadest phenotype, negative correlations were found for agreeableness (- 0.35), conscientiousness (- 0.39), and extraversion (- 0.44). A positive correlation (0.37) was found with neuroticism. Limitations: It is not possible to determine whether aspects of personality are factors in the development of bipolar disorder or vice versa. The short form of the NEO does not provide the ability to examine in detail which facets of extraversion are most closely related to bipolar disorder or to compare our results with studies that have used the long version of the scale. Conclusions: This study establishes a partial genetic basis for the Big Five personality factors in this set of families, while the environmental variances demonstrate that non-genetic factors are also important in their influence on bipolar and personality phenotypes. BPD may be most associated with decreased extraversion (less interaction with one's surroundings) because patients spend more time in depressive than manic states.

KW - Bipolar disorder

KW - Extraversion

KW - Genetic correlation

KW - Heritability

KW - Personality

UR - http://www.scopus.com/inward/record.url?scp=84857370771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857370771&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2011.04.057

DO - 10.1016/j.jad.2011.04.057

M3 - Article

VL - 136

SP - 1027

EP - 1033

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 3

ER -