Genetic regulation of plasma levels of vitamin K-dependent proteins involved in hemostasis: Results from the GAIT project

J. C. Souto, L. Almasy, J. Blangero, W. Stone, M. Borrell, T. Urrutia, J. Mateo, J. Fontcuberta

    Research output: Contribution to journalArticle

    19 Scopus citations

    Abstract

    Vitamin K-dependent proteins play a critical role in hemostasis. We have analysed the genetic and environmental correlations between measures of several vitamin K-dependent proteins in 21 Spanish extended families, including 397 individuals. Plasma functional levels of factors II, VII, IX, X, protein C and functional protein S were assayed in an automated coagulometer. Antigenic levels of total and free protein S were measured using an ELISA method. A maximum likelihood-based covariance decomposition analysis was used to assess the heritability of each trait and the genetic and environmental correlations between all possible pairs. All of the plasma levels had a significant genetic component (heritability) ranging from 22% to 52% of the phenotypic variance. Among the 28 possible pairs of genetic correlations, 18 were significant at a level of p <0.05 and six exhibited a p-value between 0.05 and 0.10. Positive environmental correlation was observed for 25 of the pairs (p <0.05). We conclude that genetic effects account for a large proportion of the observed phenotypic variation in vitamin K-dependent proteins. Some of the genes appear to pleiotropically influence all of these traits, since most pairs of phenotypes exhibit significant genetic correlation. However, since these phenotypes show a high degree of environmental correlation, it is also likely that the same environmental factors influence them co-jointly.

    Original languageEnglish (US)
    Pages (from-to)88-92
    Number of pages5
    JournalThrombosis and Haemostasis
    Volume85
    Issue number1
    StatePublished - Jan 25 2001

      Fingerprint

    Keywords

    • Genetic correlation
    • Heritability
    • Pleiotropy
    • Thrombosis
    • Vitamin K.

    ASJC Scopus subject areas

    • Hematology

    Cite this

    Souto, J. C., Almasy, L., Blangero, J., Stone, W., Borrell, M., Urrutia, T., Mateo, J., & Fontcuberta, J. (2001). Genetic regulation of plasma levels of vitamin K-dependent proteins involved in hemostasis: Results from the GAIT project. Thrombosis and Haemostasis, 85(1), 88-92.