Genetic predisposition to higher production of interleukin-6 through - 174 g > c polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia

Vanessa G. Fraga; Henrique C. Guimarães; Antônio L. Teixeira; Maira T. Barbosa; Elvis C.C. Mateo; Maria G. Carvalho; Paulo Caramelli; Karina B. Gomes

doi:10.1590/0004-282X20150137

Genetic predisposition to higher production of interleukin-6 through - 174 g > c polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia

Vanessa G. Fraga, Henrique C. Guimarães, Antônio L. Teixeira, Maira T. Barbosa, Elvis C.C. Mateo, Maria G. Carvalho, Paulo Caramelli, Karina B. Gomes

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up. Methods: The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups. Results: We observed that individuals with cognitive impairment no dementia with GG^lower genotype were more frequent among global cognitive score non-decliners while carriers of at least one C^higher allele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC_95% = 1.087-8.812). Conclusion: These results suggest that the higher expression of IL-6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia.

Original language	English (US)
Pages (from-to)	899-902
Number of pages	4
Journal	Arquivos de neuro-psiquiatria
Volume	73
Issue number	11
DOIs	https://doi.org/10.1590/0004-282X20150137
State	Published - Nov 2015
Externally published	Yes

Keywords

Cognition
Cognitive impairment no dementia
IL-6
Polymorphism

ASJC Scopus subject areas

Neurology
Clinical Neurology
Biological Psychiatry

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10.1590/0004-282X20150137

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Fraga, V. G., Guimarães, H. C., Teixeira, A. L., Barbosa, M. T., Mateo, E. C. C., Carvalho, M. G., Caramelli, P., & Gomes, K. B. (2015). Genetic predisposition to higher production of interleukin-6 through - 174 g > c polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia. Arquivos de neuro-psiquiatria, 73(11), 899-902. https://doi.org/10.1590/0004-282X20150137

Genetic predisposition to higher production of interleukin-6 through - 174 g > c polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia. / Fraga, Vanessa G.; Guimarães, Henrique C.; Teixeira, Antônio L. et al.
In: Arquivos de neuro-psiquiatria, Vol. 73, No. 11, 11.2015, p. 899-902.

Research output: Contribution to journal › Article › peer-review

Fraga, VG, Guimarães, HC, Teixeira, AL, Barbosa, MT, Mateo, ECC, Carvalho, MG, Caramelli, P & Gomes, KB 2015, 'Genetic predisposition to higher production of interleukin-6 through - 174 g > c polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia', Arquivos de neuro-psiquiatria, vol. 73, no. 11, pp. 899-902. https://doi.org/10.1590/0004-282X20150137

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abstract = "Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up. Methods: The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups. Results: We observed that individuals with cognitive impairment no dementia with GGlower genotype were more frequent among global cognitive score non-decliners while carriers of at least one Chigher allele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC95% = 1.087-8.812). Conclusion: These results suggest that the higher expression of IL-6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia.",

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AU - Barbosa, Maira T.

AU - Mateo, Elvis C.C.

AU - Carvalho, Maria G.

AU - Caramelli, Paulo

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AB - Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up. Methods: The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups. Results: We observed that individuals with cognitive impairment no dementia with GGlower genotype were more frequent among global cognitive score non-decliners while carriers of at least one Chigher allele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC95% = 1.087-8.812). Conclusion: These results suggest that the higher expression of IL-6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia.

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Genetic predisposition to higher production of interleukin-6 through - 174 g > c polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia

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