Genetic mouse models of extended lifespan

Hanyu Liang, Edward J. Masoro, James F. Nelson, Randy Strong, C. Alex McMahan, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

180 Scopus citations

Abstract

Since 1996, seven genetic mouse models have been reported to show increased lifespan: Ames and Snell dwarf mice, the 'little mouse' (Ghrhr lit/lit), mice null for either growth hormone receptor/binding protein (GHR/BP-/-) or p66shc (p66shc-/-), mice heterozygous for the IGF-I receptor (Igf1r+/-), and fat-specific insulin receptor knockout mice. In this article, we describe and evaluate these mouse models with respect to their relevance for aging studies. While these seven genetic models all show a significant increase in lifespan, issues of sample size and animal husbandry procedures require further evaluation before firm conclusions can be drawn on the reproducibility of life extension in most of these mouse models. Because data on the age-related pathology and physiological functions are lacking for all of the models, except the dwarf mice, it is too early to conclude that aging is retarded in these mouse models. However, these mouse models are already providing new information about the mechanism underlying mammalian aging.

Original languageEnglish (US)
Pages (from-to)1353-1364
Number of pages12
JournalExperimental Gerontology
Volume38
Issue number11-12
DOIs
StatePublished - 2003

Keywords

  • Caloric restriction
  • Dwarf mice
  • Growth hormone receptor binding protein
  • Insulin like growth factor-I
  • Insulin receptor

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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