Genetic influences on plasma cytokine variation in a parasitized population

Sarah Williams-Blangero, Rodrigo Corrêa-Oliveira, John L. Vandeberg, Janardan Subedi, Ram Prasad Upadhayay, Dev Raj Rai, Bharat Jha, John Blangero

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The soil-transmitted helminths are the most common helminthic infections, affecting about one-fourth of the world's population. There is a significant genetic component to susceptibility to infection with these organisms. Substantial changes in plasma cytokine levels are associated with helminthic infections, and there may be significant genetic components to this cytokine variation. Six plasma cytokine levels were assessed for 367 members of a single pedigree from the Jirel population of eastern Nepal. This population experiences moderate rates of infection with geohelminths. Sex, age, helminthic infection, infection with Giardia, and presence of a household latrine were considered as covariates in all analyses of the cytokine data. The analyses of the single Jirel pedigree revealed significant heritabilities for IFN-γ (h 2 = 0.654 ± 0.096), TNF-α (h2 = 0.458 ± 0.101), IL-2 (h2 = 0.583 ± 0.101), IL-4 (h 2 = 0.700 ± 0.095), IL-5 (h2 = 0.676 ± 0.087), and IL-10 (h2 = 0.597 ± 0.093). The ratios of IL-4 to IFN-γ and of IL-10 to IFN-γ were used as indicators of the degree of type 2 bias in immunological response; analyses of these variables indicated that approximately 40-60% of the variation (h2 = 0.400-0.577) in these derived measures of relative type 2/type 1 response is due to genetic factors.

Original languageEnglish (US)
Pages (from-to)515-525
Number of pages11
JournalHuman Biology
Volume76
Issue number4
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

cytokines
Cytokines
plasma
Infection
infection
Population
interleukin-4
Pedigree
interleukin-10
Interleukin-4
pedigree
Interleukin-10
Toilet Facilities
Giardia
interleukin-5
Nepal
Helminths
Interleukin-5
heritability
interleukin-2

Keywords

  • Cytokine variation
  • Geohelminths
  • Hookworm
  • Immunology
  • Interferon
  • Interleukin
  • Jirel population
  • Nepal
  • Parasitology
  • Roundworm
  • Tumor necrosis factor
  • Whipworm

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Williams-Blangero, S., Corrêa-Oliveira, R., Vandeberg, J. L., Subedi, J., Upadhayay, R. P., Rai, D. R., ... Blangero, J. (2004). Genetic influences on plasma cytokine variation in a parasitized population. Human Biology, 76(4), 515-525.

Genetic influences on plasma cytokine variation in a parasitized population. / Williams-Blangero, Sarah; Corrêa-Oliveira, Rodrigo; Vandeberg, John L.; Subedi, Janardan; Upadhayay, Ram Prasad; Rai, Dev Raj; Jha, Bharat; Blangero, John.

In: Human Biology, Vol. 76, No. 4, 08.2004, p. 515-525.

Research output: Contribution to journalArticle

Williams-Blangero, S, Corrêa-Oliveira, R, Vandeberg, JL, Subedi, J, Upadhayay, RP, Rai, DR, Jha, B & Blangero, J 2004, 'Genetic influences on plasma cytokine variation in a parasitized population', Human Biology, vol. 76, no. 4, pp. 515-525.
Williams-Blangero S, Corrêa-Oliveira R, Vandeberg JL, Subedi J, Upadhayay RP, Rai DR et al. Genetic influences on plasma cytokine variation in a parasitized population. Human Biology. 2004 Aug;76(4):515-525.
Williams-Blangero, Sarah ; Corrêa-Oliveira, Rodrigo ; Vandeberg, John L. ; Subedi, Janardan ; Upadhayay, Ram Prasad ; Rai, Dev Raj ; Jha, Bharat ; Blangero, John. / Genetic influences on plasma cytokine variation in a parasitized population. In: Human Biology. 2004 ; Vol. 76, No. 4. pp. 515-525.
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