Genetic imaging consortium for addiction medicine: From neuroimaging to genes

Scott Mackey, Kees Jan Kan, Bader Chaarani, Nelly Alia-Klein, Albert Batalla, Samantha Brooks, Janna Cousijn, Alain Dagher, Michiel de Ruiter, Sylvane Desrivieres, Sarah W. Feldstein Ewing, Rita Z. Goldstein, Anna E. Goudriaan, Mary M. Heitzeg, Kent Hutchison, Chiang Shan R. Li, Edythe D. London, Valentina Lorenzetti, Maartje Luijten, Rocio Martin-SantosAngelica M. Morales, Martin P. Paulus, Tomas Paus, Godfrey Pearlson, Renée Schluter, Reza Momenan, Lianne Schmaal, Gunter Schumann, Rajita Sinha, Zsuzsika Sjoerds, Dan J. Stein, Elliot A. Stein, Nadia Solowij, Susan Tapert, Anne Uhlmann, Dick Veltman, Ruth van Holst, Henrik Walter, Margaret J. Wright, Murat Yucel, Deborah Yurgelun-Todd, Derrek P. Hibar, Neda Jahanshad, Paul M. Thompson, David C. Glahn, Hugh Garavan, Patricia Conrod

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations

Abstract

Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction.The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. The deadline for contributing data to the first round of analyses occurred at the beginning of May 2015. The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.

Original languageEnglish (US)
Title of host publicationNeuroscience for Addiction Medicine
Subtitle of host publicationFrom Prevention to Rehabilitation - Methods and Interventions, 2016
EditorsHamed Ekhtiari, Martin P. Paulus
PublisherElsevier B.V.
Pages203-223
Number of pages21
ISBN (Print)9780444637161
DOIs
StatePublished - 2016
Externally publishedYes

Publication series

NameProgress in Brain Research
Volume224
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Addiction
  • ENIGMA
  • Genetic imaging
  • Neuroimaging

ASJC Scopus subject areas

  • Neuroscience(all)

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    Mackey, S., Kan, K. J., Chaarani, B., Alia-Klein, N., Batalla, A., Brooks, S., Cousijn, J., Dagher, A., de Ruiter, M., Desrivieres, S., Feldstein Ewing, S. W., Goldstein, R. Z., Goudriaan, A. E., Heitzeg, M. M., Hutchison, K., Li, C. S. R., London, E. D., Lorenzetti, V., Luijten, M., ... Conrod, P. (2016). Genetic imaging consortium for addiction medicine: From neuroimaging to genes. In H. Ekhtiari, & M. P. Paulus (Eds.), Neuroscience for Addiction Medicine: From Prevention to Rehabilitation - Methods and Interventions, 2016 (pp. 203-223). (Progress in Brain Research; Vol. 224). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2015.07.026